Nerve-specific extracellular matrix hydrogel promotes functional regeneration following nerve gap injury.
Journal
NPJ Regenerative medicine
ISSN: 2057-3995
Titre abrégé: NPJ Regen Med
Pays: United States
ID NLM: 101699846
Informations de publication
Date de publication:
25 Oct 2021
25 Oct 2021
Historique:
received:
30
11
2020
accepted:
14
09
2021
entrez:
26
10
2021
pubmed:
27
10
2021
medline:
27
10
2021
Statut:
epublish
Résumé
Nerve transection requires surgical intervention to restore function. The standard of care involves coaptation when a tension-free repair is achievable, or interposition of a graft or conduit when a gap remains. Despite advances, nerve gap injury is associated with unsatisfactory recovery. This study investigates the use of a decellularized, porcine nerve-derived hydrogel filler (peripheral nerve matrix, PNM) for conduits in an 8 mm rat sciatic nerve gap model. The decellularized tissue maintained multiple nerve-specific matrix components and nerve growth factors. This decellularized tissue was used to formulate hydrogels, which were deployed into conduits for nerve gap repair. Nerve recovery was assessed up to 24 weeks post injury by gait analysis, electrophysiology, and axon counting. Deployment of PNM within conduits was shown to improve electrophysiologic response and axon counts compared with those of empty conduit controls. These results indicate that PNM has potential benefits when used as a filler for conduits in nerve gap injuries.
Identifiants
pubmed: 34697304
doi: 10.1038/s41536-021-00174-8
pii: 10.1038/s41536-021-00174-8
pmc: PMC8546053
doi:
Types de publication
Journal Article
Langues
eng
Pagination
69Subventions
Organisme : NIBIB NIH HHS
ID : T32 EB003392
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB)
ID : EB003392
Informations de copyright
© 2021. The Author(s).
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