Lateral flow assays (LFA) as an alternative medical diagnosis method for detection of virus species: The intertwine of nanotechnology with sensing strategies.
Dengue
HBV
HIV
Influenza
Lateral flow assays
Point of care testing
SARS-CoV-2
Viral infections
Zika
Journal
Trends in analytical chemistry : TRAC
ISSN: 0165-9936
Titre abrégé: Trends Analyt Chem
Pays: Netherlands
ID NLM: 8105858
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
pubmed:
27
10
2021
medline:
27
10
2021
entrez:
26
10
2021
Statut:
ppublish
Résumé
Viruses are responsible for multiple infections in humans that impose huge health burdens on individuals and populations worldwide. Therefore, numerous diagnostic methods and strategies have been developed for prevention, management, and decreasing the burden of viral diseases, each having its advantages and limitations. Viral infections are commonly detected using serological and nucleic acid-based methods. However, these conventional and clinical approaches have some limitations that can be resolved by implementing other detector devices. Therefore, the search for sensitive, selective, portable, and costless approaches as efficient alternative clinical methods for point of care testing (POCT) analysis has gained much attention in recent years. POCT is one of the ultimate goals in virus detection, and thus, the tests need to be rapid, specific, sensitive, accessible, and user-friendly. In this review, after a brief overview of viruses and their characteristics, the conventional viral detection methods, the clinical approaches, and their advantages and shortcomings are firstly explained. Then, LFA systems working principles, benefits, classification are discussed. Furthermore, the studies regarding designing and employing LFAs in diagnosing different types of viruses, especially SARS-CoV-2 as a main concern worldwide and innovations in the LFAs' approaches and designs, are comprehensively discussed here. Furthermore, several strategies addressed in some studies for overcoming LFA limitations like low sensitivity are reviewed. Numerous techniques are adopted to increase sensitivity and perform quantitative detection. Employing several visualization methods, using different labeling reporters, integrating LFAs with other detection methods to benefit from both LFA and the integrated detection device advantages, and designing unique membranes to increase reagent reactivity, are some of the approaches that are highlighted.
Identifiants
pubmed: 34697511
doi: 10.1016/j.trac.2021.116460
pii: S0165-9936(21)00283-1
pmc: PMC8529554
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
116460Informations de copyright
© 2021 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
The authors have no conflict of interest to declare.
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