Obesity, Senescence, and Senolytics.
Adipose tissue
Cellular senescence
Obesity
SASP
Senolytics
Journal
Handbook of experimental pharmacology
ISSN: 0171-2004
Titre abrégé: Handb Exp Pharmacol
Pays: Germany
ID NLM: 7902231
Informations de publication
Date de publication:
2022
2022
Historique:
pubmed:
27
10
2021
medline:
26
7
2022
entrez:
26
10
2021
Statut:
ppublish
Résumé
Obesity is a major risk factor for the development of comorbidities such as type 2 diabetes, neurodegenerative disorders, osteoarthritis, cancer, cardiovascular and renal diseases. The onset of obesity is linked to an increase of senescent cells within adipose tissue and other organs. Cellular senescence is a stress response that has been shown to be causally linked to aging and development of various age-related diseases such as obesity. The senescence-associated-secretory phenotype of senescent cells creates a chronic inflammatory milieu that leads to local and systemic dysfunction. The elimination of senescent cells using pharmacological approaches (i.e., senolytics) has been shown to delay, prevent, or alleviate obesity-related organ dysfunction.
Identifiants
pubmed: 34697668
doi: 10.1007/164_2021_555
doi:
Substances chimiques
Senotherapeutics
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
165-180Informations de copyright
© 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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