Percutaneous Absorption of Sunscreen Filters: Review of Issues and Challenges.
Journal
Current problems in dermatology
ISSN: 1662-2944
Titre abrégé: Curr Probl Dermatol
Pays: Switzerland
ID NLM: 0147371
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
26
10
2021
pubmed:
27
10
2021
medline:
5
2
2022
Statut:
ppublish
Résumé
Although skin is a vital barrier to the outside world, it is permeable to certain substances used in topical pharmacotherapy. It is therefore not surprising that other xenobiotics intentionally or accidentally coming in contact with skin can cross the skin barrier. Long before the turn of the millennium, it became clear that sunscreen filters from sunscreen products can be systemically absorbed and detected in urine and plasma. Against this background, we review issues and challenges with safety assessments related to the possible percutaneous absorption of the sunscreen filters. A reference is made to the Regulation (EC) No. 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products (version 1 August 2018) and the concepts of the Maximal Usage Trial (MUsT) and Generally Recognized As Safe and Effective (GRASE), currently discussed in the United States.
Identifiants
pubmed: 34698027
pii: 000517595
doi: 10.1159/000517595
doi:
Substances chimiques
Sunscreening Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
188-202Informations de copyright
© 2021 S. Karger AG, Basel.