Dedifferentiated Melanoma: A Diagnostic Histological Pitfall-Review of the Literature with Case Presentation.
dedifferentiated melanoma
diagnosis
immunohistochemistry
malignant melanoma (MM)
pitfall
Journal
Dermatopathology (Basel, Switzerland)
ISSN: 2296-3529
Titre abrégé: Dermatopathology (Basel)
Pays: Switzerland
ID NLM: 101651125
Informations de publication
Date de publication:
15 Oct 2021
15 Oct 2021
Historique:
received:
07
09
2021
revised:
10
10
2021
accepted:
12
10
2021
entrez:
26
10
2021
pubmed:
27
10
2021
medline:
27
10
2021
Statut:
epublish
Résumé
Dedifferentiated melanoma is a particular form of malignant melanoma with a progressive worsening of the patient's clinical outcome. It is well known that melanoma can assume different histo-morphological patterns, to which specific genetic signatures correspond, sometimes but not always. In this review we address the diagnostic difficulties in correctly recognizing this entity, discuss the major differential diagnoses of interest to the dermatopathologist, and conduct a review of the literature with particular attention and emphasis on the latest molecular discoveries regarding the dedifferentiation/undifferentiation mechanism and more advanced therapeutic approaches.
Identifiants
pubmed: 34698090
pii: dermatopathology8040051
doi: 10.3390/dermatopathology8040051
pmc: PMC8544555
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
494-501Références
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