Formulation and In-Vitro Characterization of pH-Responsive Semi-Interpenetrating Polymer Network Hydrogels for Controlled Release of Ketorolac Tromethamine.
carbopol 934
hydrogel
ketorolac tromethamine
sodium polystyrene sulfonate
Journal
Gels (Basel, Switzerland)
ISSN: 2310-2861
Titre abrégé: Gels
Pays: Switzerland
ID NLM: 101696925
Informations de publication
Date de publication:
13 Oct 2021
13 Oct 2021
Historique:
received:
06
09
2021
revised:
06
10
2021
accepted:
09
10
2021
entrez:
26
10
2021
pubmed:
27
10
2021
medline:
27
10
2021
Statut:
epublish
Résumé
Ketorolac tromethamine is a non-steroidal anti-inflammatory drug used in the management of severe pain. The half-life of Ketorolac tromethamine is within the range of 2.5-4 h. Hence, repeated doses of Ketorolac tromethamine are needed in a day to maintain the therapeutic level. However, taking several doses of Ketorolac tromethamine in a day generates certain complications, such as acute renal failure and gastrointestinal ulceration. Therefore, a polymeric-controlled drug delivery system is needed that could prolong the release of Ketorolac tromethamine. Therefore, in the current study, pH-responsive carbopol 934/sodium polystyrene sulfonate-co-poly(acrylic acid) (CP/SpScPAA) hydrogels were developed by the free radical polymerization technique for the controlled release of Ketorolac tromethamine. Monomer acrylic acid was crosslinked with the polymers carbopol 934 and sodium polystyrene sulfonate by the cross-linker
Identifiants
pubmed: 34698162
pii: gels7040167
doi: 10.3390/gels7040167
pmc: PMC8544598
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Science Council of Taiwan
ID : MOST 110-2320-B-037-014-MY2
Organisme : Kaohsiung Medical University Research Foundation
ID : KMU-TC109A03-1
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