Physician Perspectives on Including Pregnant Women in Covid-19 Clinical Trials: Time for a Paradigm Change.
Covid-19 clinical trials
human subjects research
inclusion of pregnant women in trials
maternal-fetal ethics
pregnant research participants
research with pregnant women
Journal
Ethics & human research
ISSN: 2578-2363
Titre abrégé: Ethics Hum Res
Pays: United States
ID NLM: 101738005
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
pubmed:
27
10
2021
medline:
11
11
2021
entrez:
26
10
2021
Statut:
ppublish
Résumé
Excluding pregnant people from Covid-19 clinical trials may lead to unintended harmful consequences. For this study, an online questionnaire was sent to physicians belonging to Canadian professional medical associations in order to evaluate their perspectives on the participation of pregnant women in Covid-19 clinical trials. The majority of respondents expressed support for including pregnant women in Covid-19 trials (119/165; 72%), especially those investigating therapies with a prior safety record in pregnancy (139/164; 85%). The main perceived barriers to inclusion identified were unwillingness of pregnant patients to participate and of treating teams to offer participation, the burden of regulatory approval, and a general "culture of exclusion" of pregnant women from trials. We describe why some physicians may be reluctant to include pregnant individuals in trials, and we identify barriers to the appropriate participation of pregnant people in clinical research.
Identifiants
pubmed: 34699138
doi: 10.1002/eahr.500107
pmc: PMC8652879
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
19-27Informations de copyright
© 2021 by The Hastings Center. All rights reserved.
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