Alterations of DNA methylation during adipogenesis differentiation of mesenchymal stem cells isolated from adipose tissue of patients with obesity is associated with type 2 diabetes.
Adipogenesis
DNA methylation
obesity
type 2 diabetes
Journal
Adipocyte
ISSN: 2162-397X
Titre abrégé: Adipocyte
Pays: United States
ID NLM: 101567863
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
entrez:
26
10
2021
pubmed:
27
10
2021
medline:
14
1
2022
Statut:
ppublish
Résumé
Adipogenesis regulation is crucial for mature adipocyte function. In obesity, a major driver of type 2 diabetes (T2D), this process is disrupted and remains poorly characterized. Here we identified altered DNA methylation profiles in diabetic obese patients, during three adipocytes differentiation stages. We isolated mesenchymal cells from visceral adipose tissue of obese patients with and without T2D to analyse DNA methylation profiles at 0, 3, and 18 days of
Identifiants
pubmed: 34699309
doi: 10.1080/21623945.2021.1978157
pmc: PMC8555535
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
493-504Références
Int J Obes (Lond). 2019 Feb;43(2):306-318
pubmed: 29511320
Int J Mol Sci. 2019 Aug 12;20(16):
pubmed: 31408999
Oncotarget. 2017 Feb 14;8(7):11442-11459
pubmed: 28077797
Biochem Biophys Res Commun. 2015 Nov 27;467(4):979-86
pubmed: 26462465
Lipids Health Dis. 2019 Mar 18;18(1):68
pubmed: 30885219
Stem Cells Int. 2018 Jul 22;2018:3569493
pubmed: 30154863
Epigenomics. 2016 Dec;8(12):1601-1617
pubmed: 27854126
Circ Res. 2012 Apr 13;110(8):1039-41
pubmed: 22499895
Obesity (Silver Spring). 2019 Aug;27(8):1292-1304
pubmed: 31338999
Stem Cells. 2011 Jul;29(7):1034-40
pubmed: 21544899
Exp Mol Med. 2017 Apr 28;49(4):e322
pubmed: 28450738
Nephrol Dial Transplant. 2016 Mar;31(3):413-23
pubmed: 26516203
Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
PLoS One. 2011 Apr 12;6(4):e18284
pubmed: 21532749
Nat Genet. 2018 Jan;50(1):26-41
pubmed: 29273807
Arch Med Sci. 2014 Oct 27;10(5):855-62
pubmed: 25395935
Compr Psychoneuroendocrinol. 2020 Nov;4:
pubmed: 35355831
Tissue Eng. 2001 Apr;7(2):211-28
pubmed: 11304456
EMBO Rep. 2016 May;17(5):638-47
pubmed: 27113764
Nat Med. 2019 Sep;25(9):1385-1389
pubmed: 31501613
Nat Rev Mol Cell Biol. 2011 Sep 28;12(11):722-34
pubmed: 21952300
Int J Obes (Lond). 2015 Nov;39(11):1662-5
pubmed: 26238973
Nat Rev Mol Cell Biol. 2006 Dec;7(12):885-96
pubmed: 17139329
Diabetes. 2014 Sep;63(9):2962-76
pubmed: 24812430
J Clin Med. 2019 Jan 13;8(1):
pubmed: 30642114
Nat Rev Mol Cell Biol. 2019 Apr;20(4):242-258
pubmed: 30610207
Elife. 2017 Dec 05;6:
pubmed: 29205155
PLoS Genet. 2015 Dec 01;11(12):e1005694
pubmed: 26624892
Nat Commun. 2019 Sep 6;10(1):4064
pubmed: 31492854
Biochem J. 2005 Apr 15;387(Pt 2):343-53
pubmed: 15563274
Cell Stem Cell. 2017 Jun 1;20(6):771-784.e6
pubmed: 28330582
BMJ Open. 2017 Nov 15;7(11):e017875
pubmed: 29146643
Bioinformatics. 2010 Oct 1;26(19):2363-7
pubmed: 20688976
Mol Metab. 2019 Dec;30:48-60
pubmed: 31767180
Stem Cell Rev Rep. 2018 Jun;14(3):337-345
pubmed: 29611042
Mol Biol Cell. 2016 Aug 15;27(16):2523-7
pubmed: 27528697
Cancer Cell. 2009 Apr 7;15(4):304-14
pubmed: 19345329
Cell Metab. 2011 Nov 2;14(5):569-70
pubmed: 22055498
Nat Rev Endocrinol. 2019 Apr;15(4):207-225
pubmed: 30733616
J Cell Mol Med. 2019 Feb;23(2):702-710
pubmed: 30402908
Muscles Ligaments Tendons J. 2012 Oct 16;2(3):154-62
pubmed: 23738292
Stem Cell Reports. 2017 Apr 11;8(4):947-960
pubmed: 28344004
Mol Cell Biol. 2015 May;35(10):1686-99
pubmed: 25733684
BMC Med Genet. 2018 Feb 21;19(1):28
pubmed: 29466957
Sci Rep. 2018 Apr 30;8(1):6709
pubmed: 29712937
Pharmacogenet Genomics. 2010 Aug;20(8):476-84
pubmed: 20562673
Biochim Biophys Acta. 2014 Mar;1842(3):431-9
pubmed: 23735217
Nature. 2008 Jun 5;453(7196):783-7
pubmed: 18454136
J Allergy Clin Immunol. 2020 Feb;145(2):537-549
pubmed: 31669095
Cytokine Growth Factor Rev. 2010 Dec;21(6):449-53
pubmed: 21084215
Mol Cell Biol. 2000 Feb;20(3):1008-20
pubmed: 10629058
Diabetes Care. 2019 Mar;42(3):466-475
pubmed: 30659075
J Med Invest. 2017;64(3.4):193-196
pubmed: 28954980
Trends Endocrinol Metab. 2009 Jan;20(1):16-24
pubmed: 19008118
Mol Metab. 2016 Jan 02;5(3):171-183
pubmed: 26977391
Biochim Biophys Acta. 2012 Jun;1821(6):914-22
pubmed: 22405860
Mol Cell Endocrinol. 2012 Nov 25;364(1-2):36-45
pubmed: 22939844
Sci Rep. 2019 Mar 19;9(1):4855
pubmed: 30890718
Int J Obes (Lond). 2016 Jan;40(1):102-11
pubmed: 26122028
Cell Signal. 2018 Dec;52:155-162
pubmed: 30223017
Glycobiology. 2017 Jan;27(2):129-139
pubmed: 27683310
Hum Genet. 2015 Feb;134(2):247-57
pubmed: 25487307
Biochem Biophys Res Commun. 2003 Jun 13;305(4):981-8
pubmed: 12767927
Bioinformatics. 2017 Dec 15;33(24):3982-3984
pubmed: 28961746
Diabetologia. 2015 Mar;58(3):443-55
pubmed: 25481708
Cell Signal. 2020 Nov;75:109735
pubmed: 32795510