Dpp/TGFβ-superfamily play a dual conserved role in mediating the damage response in the retina.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
05
2021
accepted:
06
10
2021
entrez:
26
10
2021
pubmed:
27
10
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Retinal homeostasis relies on intricate coordination of cell death and survival in response to stress and damage. Signaling mechanisms that coordinate this process in the adult retina remain poorly understood. Here we identify Decapentaplegic (Dpp) signaling in Drosophila and its mammalian homologue Transforming Growth Factor-beta (TGFβ) superfamily, that includes TGFβ and Bone Morphogenetic Protein (BMP) signaling arms, as central mediators of retinal neuronal death and tissue survival following acute damage. Using a Drosophila model for UV-induced retinal damage, we show that Dpp released from immune cells promotes tissue loss after UV-induced retinal damage. Interestingly, we find a dynamic response of retinal cells to this signal: in an early phase, Dpp-mediated stimulation of Saxophone/Smox signaling promotes apoptosis, while at a later stage, stimulation of the Thickveins/Mad axis promotes tissue repair and survival. This dual role is conserved in the mammalian retina through the TGFβ/BMP signaling, as supplementation of BMP4 or inhibition of TGFβ using small molecules promotes retinal cell survival, while inhibition of BMP negatively affects cell survival after light-induced photoreceptor damage and NMDA induced inner retinal neuronal damage. Our data identify key evolutionarily conserved mechanisms by which retinal homeostasis is maintained.
Identifiants
pubmed: 34699550
doi: 10.1371/journal.pone.0258872
pii: PONE-D-21-17742
pmc: PMC8547621
doi:
Substances chimiques
Drosophila Proteins
0
Receptors, Transforming Growth Factor beta
0
Transforming Growth Factor beta
0
dpp protein, Drosophila
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0258872Subventions
Organisme : NEI NIH HHS
ID : R01 EY025779
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY032197
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057353
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY018177
Pays : United States
Déclaration de conflit d'intérêts
I have read the journal’s policy and the following authors of this manuscript have the following competing interests: Heinrich Jasper is an employee of Genentech Inc. This commercial affiliation does not alter author’s adherence to all PLOS ONE policies on sharing data and materials.
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