Modulation of the Host Cell Transcriptome and Epigenome by Fusobacterium nucleatum.
Fusobacterium
Fusobacterium nucleatum
colorectal cancer
epigenome
host response
infection
oncomicrobe
transcriptome
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
26 10 2021
26 10 2021
Historique:
entrez:
27
10
2021
pubmed:
28
10
2021
medline:
4
2
2022
Statut:
ppublish
Résumé
Fusobacterium nucleatum is a ubiquitous opportunistic pathogen with an emerging role as an oncomicrobe in colorectal cancer and other cancer settings. F. nucleatum can adhere to and invade host cells in a manner that varies across F. nucleatum strains and host cell phenotypes. Here, we performed pairwise cocultures between three F. nucleatum strains and two immortalized primary host cell types (human colonic epithelial [HCE] cells and human carotid artery endothelial [HCAE] cells) followed by transcriptome sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq) to investigate transcriptional and epigenetic host cell responses. We observed that F. nucleatum-induced host cell transcriptional modulation involves strong upregulation of genes related to immune migration and inflammatory processes, such as
Identifiants
pubmed: 34700376
doi: 10.1128/mBio.02062-21
pmc: PMC8546542
doi:
Substances chimiques
CCL20 protein, human
0
Chemokine CCL20
0
Dual Oxidases
EC 1.11.1.-
DUOX2 protein, human
EC 1.6.3.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0206221Subventions
Organisme : Cancer Research UK
ID : A27140
Pays : United Kingdom
Organisme : CIHR
Pays : Canada
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