Intubated COVID-19 predictive (ICOP) score for early mortality after intubation in patients with COVID-19.
Adolescent
Adult
Age Factors
Aged
Arterial Pressure
COVID-19
/ diagnosis
Female
Ferritins
/ blood
Humans
Hydrogen-Ion Concentration
Intubation, Intratracheal
/ methods
Male
Middle Aged
New York
Nitrogen
/ metabolism
Oxygen
/ metabolism
Predictive Value of Tests
ROC Curve
Regression Analysis
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Severity of Illness Index
Vasoconstrictor Agents
/ pharmacology
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
26 10 2021
26 10 2021
Historique:
received:
12
03
2021
accepted:
15
09
2021
entrez:
27
10
2021
pubmed:
28
10
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Patients with coronavirus disease 2019 (COVID-19) can have increased risk of mortality shortly after intubation. The aim of this study is to develop a model using predictors of early mortality after intubation from COVID-19. A retrospective study of 1945 intubated patients with COVID-19 admitted to 12 Northwell hospitals in the greater New York City area was performed. Logistic regression model using backward selection was applied. This study evaluated predictors of 14-day mortality after intubation for COVID-19 patients. The predictors of mortality within 14 days after intubation included older age, history of chronic kidney disease, lower mean arterial pressure or increased dose of required vasopressors, higher urea nitrogen level, higher ferritin, higher oxygen index, and abnormal pH levels. We developed and externally validated an intubated COVID-19 predictive score (ICOP). The area under the receiver operating characteristic curve was 0.75 (95% CI 0.73-0.78) in the derivation cohort and 0.71 (95% CI 0.67-0.75) in the validation cohort; both were significantly greater than corresponding values for sequential organ failure assessment (SOFA) or CURB-65 scores. The externally validated predictive score may help clinicians estimate early mortality risk after intubation and provide guidance for deciding the most effective patient therapies.
Identifiants
pubmed: 34702896
doi: 10.1038/s41598-021-00591-1
pii: 10.1038/s41598-021-00591-1
pmc: PMC8548515
doi:
Substances chimiques
Vasoconstrictor Agents
0
Ferritins
9007-73-2
Nitrogen
N762921K75
Oxygen
S88TT14065
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
21124Subventions
Organisme : NLM NIH HHS
ID : R01 LM012836
Pays : United States
Organisme : NIA NIH HHS
ID : R24 AG064191
Pays : United States
Organisme : the National Library of Medicine of the National Institutes of Health
ID : R01LM012836
Organisme : the National Institute on Aging of the National Institutes of Health
ID : R24AG064191
Investigateurs
Matthew A Barish
(MA)
Douglas P Barnaby
(DP)
Santiago J Miyara
(SJ)
Edith Burns
(E)
Stuart L Cohen
(SL)
Jennifer Cookingham
(J)
Andrew J Dominello
(AJ)
Jennifer C Johnson
(JC)
Zachary M Kozel
(ZM)
Brian Lima
(B)
Ariana K McGinn
(AK)
Ernesto P Molmenti
(EP)
Rachel Monane
(R)
Marc D Paradis
(M)
Informations de copyright
© 2021. The Author(s).
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