Hip Replacement in Ankylosing Spondylitis Patients with Advanced Hip Involvement: Factors Associated with Bilateral Total Hip Arthroplasty.
ankylosing spondylitis
anti-TNF therapy
bilateral total hip arthroplasty
hip involvement
Journal
International journal of general medicine
ISSN: 1178-7074
Titre abrégé: Int J Gen Med
Pays: New Zealand
ID NLM: 101515487
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
08
2021
accepted:
01
10
2021
entrez:
27
10
2021
pubmed:
28
10
2021
medline:
28
10
2021
Statut:
epublish
Résumé
This study aimed to compare the clinical data of ankylosing spondylitis (AS) patients who underwent unilateral and bilateral total hip arthroplasty (THA) due to advanced hip involvement. Furthermore, to determine the factors associated with bilateral THA. Utilizing a single-institution database, we selected 373 consecutive AS patients undergoing primary THA from 2012 to 2017 and compared the clinical characteristics and anti-tumor necrosis factor (TNF) therapy of the patients who underwent unilateral and bilateral THA. Logistic regression was used to identify factors associated with bilateral THA. Bilateral THA was performed in 67.3% (n=251) of the patients. Male patients had a higher frequency of undergoing bilateral THA compared with female ones (P<0.05). The proportion of the patients who had bilateral onset in hips, administration of TNF inhibitors, flexion contracture in the hip, and a BASRI-hip score of 4 was significantly higher in patients with bilateral THA than that with unilateral THA (P<0.05). Patients with bilateral THA experienced longer disease duration than those with unilateral THA (P<0.05). The results of the logistic regression showed that factors related to bilateral THA were bilateral onset in hips, administration of TNF inhibitors, a BASRI-hip score of 4, and an erythrocyte sedimentation rate (ESR) level (P<0.05). Bilateral THA is more common in AS patients with advanced hip involvement. Bilateral onset in hips, a BASRI-hip score of 4, and a higher level of ESR are risk factors associated with bilateral THA, while anti-TNF therapy is a protective factor reducing the progression of hip involvement to bilateral THA.
Sections du résumé
BACKGROUND
BACKGROUND
This study aimed to compare the clinical data of ankylosing spondylitis (AS) patients who underwent unilateral and bilateral total hip arthroplasty (THA) due to advanced hip involvement. Furthermore, to determine the factors associated with bilateral THA.
METHODS
METHODS
Utilizing a single-institution database, we selected 373 consecutive AS patients undergoing primary THA from 2012 to 2017 and compared the clinical characteristics and anti-tumor necrosis factor (TNF) therapy of the patients who underwent unilateral and bilateral THA. Logistic regression was used to identify factors associated with bilateral THA.
RESULTS
RESULTS
Bilateral THA was performed in 67.3% (n=251) of the patients. Male patients had a higher frequency of undergoing bilateral THA compared with female ones (P<0.05). The proportion of the patients who had bilateral onset in hips, administration of TNF inhibitors, flexion contracture in the hip, and a BASRI-hip score of 4 was significantly higher in patients with bilateral THA than that with unilateral THA (P<0.05). Patients with bilateral THA experienced longer disease duration than those with unilateral THA (P<0.05). The results of the logistic regression showed that factors related to bilateral THA were bilateral onset in hips, administration of TNF inhibitors, a BASRI-hip score of 4, and an erythrocyte sedimentation rate (ESR) level (P<0.05).
CONCLUSION
CONCLUSIONS
Bilateral THA is more common in AS patients with advanced hip involvement. Bilateral onset in hips, a BASRI-hip score of 4, and a higher level of ESR are risk factors associated with bilateral THA, while anti-TNF therapy is a protective factor reducing the progression of hip involvement to bilateral THA.
Identifiants
pubmed: 34703290
doi: 10.2147/IJGM.S336314
pii: 336314
pmc: PMC8526512
doi:
Types de publication
Journal Article
Langues
eng
Pagination
6857-6862Informations de copyright
© 2021 Li et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
Références
Mod Rheumatol. 2016 Nov;26(6):933-939
pubmed: 26872512
Ann Rheum Dis. 2007 Aug;66(8):1072-7
pubmed: 17261531
J Rheumatol. 2017 Nov;44(11):1759-1760
pubmed: 29093078
EFORT Open Rev. 2019 Jul 17;4(7):476-481
pubmed: 31423331
Rheumatology (Oxford). 2019 Jun 1;58(6):1040-1046
pubmed: 30624693
Br J Rheumatol. 1988 Oct;27(5):393-5
pubmed: 3179629
Arthritis Rheum. 1984 Apr;27(4):361-8
pubmed: 6231933
J Rheumatol. 2000 Dec;27(12):2866-72
pubmed: 11128678
J Rheumatol. 2015 Jan;42(1):106-10
pubmed: 25362650
J Bone Joint Surg Am. 1997 Aug;79(8):1181-9
pubmed: 9278078
Cochrane Database Syst Rev. 2015 Apr 18;(4):CD005468
pubmed: 25887212
Ann Rheum Dis. 2011 Jun;70(6):896-904
pubmed: 21540199
Clin Rheumatol. 2013 Aug;32(8):1229-32
pubmed: 23604596
Arthritis Rheum. 2009 Nov 15;61(11):1484-90
pubmed: 19877087
J Arthroplasty. 2002 Jun;17(4):427-33
pubmed: 12066271
J Arthroplasty. 2020 Sep;35(9):2573-2580
pubmed: 32418748
J Bone Joint Surg Br. 2006 Mar;88(3):298-303
pubmed: 16498000
Rheumatology (Oxford). 2010 Jan;49(1):73-81
pubmed: 19605374
J Arthroplasty. 1996 Oct;11(7):802-12
pubmed: 8934320
Arthritis Rheum. 1976 Jul-Aug;19(4):683-92
pubmed: 942499
Joint Bone Spine. 2011 Oct;78(5):531-2
pubmed: 21570332
Int Orthop. 2012 Apr;36(4):697-701
pubmed: 21751023
Ann Rheum Dis. 1979 Aug;38(4):332-6
pubmed: 496447
Curr Opin Rheumatol. 2013 Jul;25(4):448-54
pubmed: 23689637
Ann Rheum Dis. 2014 Jun;73(6):1194-7
pubmed: 24285490
Ann Rheum Dis. 2015 Jun;74(6):1241-8
pubmed: 24718959
Rheumatol Int. 2012 Jun;32(6):1663-7
pubmed: 21387110
Clin Rheumatol. 2021 May;40(5):1881-1887
pubmed: 33230684