Towards optimizing peptide-based inhibitors of protein-protein interactions: predictive saturation variation scanning (PreSaVS).


Journal

RSC chemical biology
ISSN: 2633-0679
Titre abrégé: RSC Chem Biol
Pays: England
ID NLM: 101768727

Informations de publication

Date de publication:
07 Oct 2021
Historique:
received: 26 06 2021
accepted: 30 07 2021
entrez: 27 10 2021
pubmed: 28 10 2021
medline: 28 10 2021
Statut: epublish

Résumé

A simple-to-implement and experimentally validated computational workflow for sequence modification of peptide inhibitors of protein-protein interactions (PPIs) is described.

Identifiants

pubmed: 34704051
doi: 10.1039/d1cb00137j
pii: d1cb00137j
pmc: PMC8495968
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1474-1478

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L01386X/1
Pays : United Kingdom

Informations de copyright

This journal is © The Royal Society of Chemistry.

Déclaration de conflit d'intérêts

There are no conflicts to declare.

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Auteurs

Kristina Hetherington (K)

Astbury Centre for Structural Molecular Biology, University of Leeds Woodhouse Lane Leeds LS2 9JT UK a.j.wilson@leeds.ac.uk.
School of Chemistry, University of Leeds Woodhouse Lane Leeds LS2 9JT UK.

Som Dutt (S)

Astbury Centre for Structural Molecular Biology, University of Leeds Woodhouse Lane Leeds LS2 9JT UK a.j.wilson@leeds.ac.uk.
School of Chemistry, University of Leeds Woodhouse Lane Leeds LS2 9JT UK.

Amaurys A Ibarra (AA)

School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk Bristol BS8 1TD UK r.sessions@bristol.ac.uk.

Emma E Cawood (EE)

Astbury Centre for Structural Molecular Biology, University of Leeds Woodhouse Lane Leeds LS2 9JT UK a.j.wilson@leeds.ac.uk.
School of Chemistry, University of Leeds Woodhouse Lane Leeds LS2 9JT UK.

Fruzsina Hobor (F)

Astbury Centre for Structural Molecular Biology, University of Leeds Woodhouse Lane Leeds LS2 9JT UK a.j.wilson@leeds.ac.uk.
School of Molecular and Cellular Biology, University of Leeds Woodhouse Lane Leeds LS2 9JT UK.

Derek N Woolfson (DN)

School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk Bristol BS8 1TD UK r.sessions@bristol.ac.uk.
School of Chemistry, University of Bristol, Cantock's Close Bristol BS8 1TS UK.
BrisSynBio, University of Bristol, Life Sciences Building Tyndall Avenue Bristol BS8 1TQ UK.

Thomas A Edwards (TA)

Astbury Centre for Structural Molecular Biology, University of Leeds Woodhouse Lane Leeds LS2 9JT UK a.j.wilson@leeds.ac.uk.
School of Molecular and Cellular Biology, University of Leeds Woodhouse Lane Leeds LS2 9JT UK.

Adam Nelson (A)

Astbury Centre for Structural Molecular Biology, University of Leeds Woodhouse Lane Leeds LS2 9JT UK a.j.wilson@leeds.ac.uk.
School of Chemistry, University of Leeds Woodhouse Lane Leeds LS2 9JT UK.

Richard B Sessions (RB)

School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk Bristol BS8 1TD UK r.sessions@bristol.ac.uk.
BrisSynBio, University of Bristol, Life Sciences Building Tyndall Avenue Bristol BS8 1TQ UK.

Andrew J Wilson (AJ)

Astbury Centre for Structural Molecular Biology, University of Leeds Woodhouse Lane Leeds LS2 9JT UK a.j.wilson@leeds.ac.uk.
School of Chemistry, University of Leeds Woodhouse Lane Leeds LS2 9JT UK.

Classifications MeSH