Alloantigen-specific type 1 regulatory T cells suppress through CTLA-4 and PD-1 pathways and persist long-term in patients.


Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
27 Oct 2021
Historique:
entrez: 27 10 2021
pubmed: 28 10 2021
medline: 3 11 2021
Statut: ppublish

Résumé

Type 1 regulatory T (Tr1) cells are inducible, interleukin (IL)-10

Identifiants

pubmed: 34705520
doi: 10.1126/scitranslmed.abf5264
pmc: PMC9451143
mid: NIHMS1780720
doi:

Substances chimiques

CTLA-4 Antigen 0
Isoantigens 0
Programmed Cell Death 1 Receptor 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabf5264

Subventions

Organisme : NCI NIH HHS
ID : P01 CA049605
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK116074
Pays : United States
Organisme : NIH HHS
ID : S10 OD018220
Pays : United States

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Auteurs

Pauline P Chen (PP)

Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.

Alma-Martina Cepika (AM)

Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.

Rajni Agarwal-Hashmi (R)

Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.

Gopin Saini (G)

Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Center for Definitive and Curative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Molly J Uyeda (MJ)

Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

David M Louis (DM)

Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.

Brandon Cieniewicz (B)

Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.

Mansi Narula (M)

Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.

Laura C Amaya Hernandez (LC)

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Nicholas Harre (N)

Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.

Liwen Xu (L)

Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stanford Functional Genomics Facility, Stanford University School of Medicine, Stanford, CA 94305, USA.

Benjamin Craig Thomas (BC)

Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.

Xuhuai Ji (X)

Stanford Functional Genomics Facility, Stanford University School of Medicine, Stanford, CA 94305, USA.

Parveen Shiraz (P)

Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Keri M Tate (KM)

Stanford Laboratory for Cell and Gene Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Dana Margittai (D)

Stanford Laboratory for Cell and Gene Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Neehar Bhatia (N)

Stanford Laboratory for Cell and Gene Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Everett Meyer (E)

Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Alice Bertaina (A)

Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Center for Definitive and Curative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Mark M Davis (MM)

Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

Rosa Bacchetta (R)

Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Center for Definitive and Curative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Maria Grazia Roncarolo (MG)

Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Center for Definitive and Curative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Classifications MeSH