Prostatic fluid composition and semen quality in dogs with benign prostatic hyperplasia undergoing treatment with osaterone acetate.
Benign prostatic hyperplasia
osaterone acetate
prostate
prostatic fluid
semen quality
Journal
Reproduction in domestic animals = Zuchthygiene
ISSN: 1439-0531
Titre abrégé: Reprod Domest Anim
Pays: Germany
ID NLM: 9015668
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
14
08
2021
accepted:
19
10
2021
pubmed:
28
10
2021
medline:
18
1
2022
entrez:
27
10
2021
Statut:
ppublish
Résumé
Benign prostatic hyperplasia (BPH) may alter prostatic fluid biochemical composition causing reduced fertility. Osaterone acetate (OA) is an androgen receptor antagonist marketed for treatment of canine BPH. Little information exists on effects of OA administration on biochemical composition of canine prostatic fluid and its role on fertility. The aim of this research was to study biochemical composition of prostatic fluid and its role on semen quality in dogs with BPH undergoing treatment with OA. Eight intact, 5-11-year-old dogs with benign prostatic hyperplasia were treated orally with OA at a dose of 0.25-0.5 mg/kg once daily for seven days. Prostatic volume, semen evaluation and a biochemical analysis of prostatic fluid were performed on the day before treatment (D0), D60, D120, D180 and D240. A significant reduction (57% and 61%) of prostatic volume was observed at D60 and D120, respectively, and a significant reduction (20%) of normal spermatozoa was observed at D60 coincident with a significant increase of sperm tail defects, which disappeared during the course of the treatment. Prostatic fluid composition did not vary during the OA treatment except for zinc (Zn
Substances chimiques
Chlormadinone Acetate
0SY050L61N
osaterone acetate
FR26FSV5EZ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
72-79Informations de copyright
© 2021 Wiley-VCH GmbH.
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