First evidence of human-to-dog transmission of SARS-CoV-2 B.1.160 variant in France.
B.1.160 variant
COVID-19
France
Marseille-4 variant
SARS-CoV-2
dog
epidemiology
genome
Journal
Transboundary and emerging diseases
ISSN: 1865-1682
Titre abrégé: Transbound Emerg Dis
Pays: Germany
ID NLM: 101319538
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
revised:
28
08
2021
received:
01
07
2021
accepted:
15
10
2021
pubmed:
28
10
2021
medline:
22
7
2022
entrez:
27
10
2021
Statut:
ppublish
Résumé
Since the start of the coronavirus disease of 2019 (COVID-19) pandemic, several episodes of human-to-animal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission have been described in different countries. The role of pets, especially domestic dogs, in the COVID-19 epidemiology is highly questionable and needs further investigation. In this study, we report a case of COVID-19 in a French dog living in close contact with its owners who were COVID-19 patients. The dog presented rhinitis and was sampled 1 week after its owners (a man and a woman) were tested positive for COVID-19. The nasal swabs for the dog tested remained positive for SARS-CoV-2 by reverse transcription quantitative real-time PCR (RT-qPCR) 1 month following the first diagnosis. Specific anti-SARS-CoV-2 antibodies were detectable 12 days after the first diagnosis and persisted for at least 5 months as tested using enzyme-linked immunoassay (ELISA) and automated western blotting. The whole-genome sequences from the dog and its owners were 99%-100% identical (with the man and the woman's sequences, respectively) and matched the B.1.160 variant of concern (Marseille-4 variant), the most widespread in France at the time the dog was infected. This study documents the first detection of B.1.160 in pets (a dog) in France, and the first canine genome recovery of the B.1.160 variant of global concern. Moreover, given the enhanced infectivity and transmissibility of the Marseille-4 variant for humans, this case also highlights the risk that pets may potentially play a significant role in SARS-CoV-2 outbreaks and may transmit the infection to humans. We have evidence of human-to-dog transmission of the Marseille-4 variant since the owners were first to be infected. Finally, owners and veterinarians must be vigilent for canine COVID-19 when dogs are presented with respiratory clinical signs.
Identifiants
pubmed: 34706153
doi: 10.1111/tbed.14359
pmc: PMC8662256
doi:
Substances chimiques
Antibodies, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e823-e830Subventions
Organisme : the Institut Hospitalo-Universitaire (IHU) Méditerranée Infection
ID : ANR-10-IAHU-03
Organisme : the Region Provence-Alpes-Côte d'Azur
Organisme : ERDF PRIMI
Informations de copyright
© 2021 The Authors. Transboundary and Emerging Diseases published by Wiley-VCH GmbH.
Références
Biochem Biophys Res Commun. 2020 May 21;526(1):165-169
pubmed: 32201080
Science. 2021 Jan 8;371(6525):172-177
pubmed: 33172935
Transbound Emerg Dis. 2022 Jul;69(4):e823-e830
pubmed: 34706153
Vet Res Commun. 2021 Feb;45(1):1-19
pubmed: 33464439
PLoS One. 2021 Apr 28;16(4):e0250853
pubmed: 33909706
Clin Microbiol Infect. 2021 Sep;27(9):1352.e1-1352.e5
pubmed: 33991677
Emerg Infect Dis. 2021;27(7):1981-1984
pubmed: 33979566
Nat Commun. 2020 Dec 4;11(1):6231
pubmed: 33277505
Curr Biol. 2020 Apr 6;30(7):1346-1351.e2
pubmed: 32197085
Science. 2020 May 29;368(6494):1016-1020
pubmed: 32269068
J Small Anim Pract. 2021 May;62(5):336-342
pubmed: 33521974
Eur J Clin Microbiol Infect Dis. 2020 Jun;39(6):1059-1061
pubmed: 32342252
Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26382-26388
pubmed: 32994343
Front Microbiol. 2021 Apr 01;12:663815
pubmed: 33868218
Int J Antimicrob Agents. 2020 Jul;56(1):105949
pubmed: 32205204
Travel Med Infect Dis. 2020 Jul - Aug;36:101632
pubmed: 32205269
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Mol Biol Evol. 2013 Apr;30(4):772-80
pubmed: 23329690
Nature. 2020 Oct;586(7831):776-778
pubmed: 32408337
Viruses. 2021 Jan 26;13(2):
pubmed: 33530620
N Engl J Med. 2020 Aug 6;383(6):592-594
pubmed: 32402157
Front Vet Sci. 2021 Feb 10;8:619207
pubmed: 33644148
J Biol Chem. 2021 Jan-Jun;296:100435
pubmed: 33610551
Eur J Clin Microbiol Infect Dis. 2021 Jun;40(6):1309-1317
pubmed: 33660134
Nature. 2021 Jul;595(7869):707-712
pubmed: 34098568
One Health. 2020 Dec;10:100133
pubmed: 32363229
Front Vet Sci. 2020 Sep 24;7:582287
pubmed: 33195600
One Health. 2021 Jul 18;13:100293
pubmed: 34377760
Travel Med Infect Dis. 2020 May - Jun;35:101738
pubmed: 32387409
Microorganisms. 2021 Apr 17;9(4):
pubmed: 33920724
Transbound Emerg Dis. 2022 May;69(3):1656-1658
pubmed: 33955193
Eur J Clin Microbiol Infect Dis. 2021 Feb;40(2):361-371
pubmed: 33179133
Int J Infect Dis. 2021 May;106:228-236
pubmed: 33785459
J Virol. 2020 Jul 16;94(15):
pubmed: 32404529
Pathogens. 2020 Jun 18;9(6):
pubmed: 32570713
One Health. 2020 Dec;10:100164
pubmed: 32904469
Transbound Emerg Dis. 2020 Nov;67(6):2324-2328
pubmed: 32500944
One Health. 2021 Jun;11:100192
pubmed: 33169106
Viruses. 2021 Mar 17;13(3):
pubmed: 33802899
Bioinformatics. 2018 Sep 15;34(18):3094-3100
pubmed: 29750242