Adolescent
Adult
Bone Neoplasms
/ pathology
Female
Fluorine Radioisotopes
/ pharmacology
Humans
Lung Neoplasms
/ radiotherapy
Neoplasm Metastasis
/ radiotherapy
Osteoblastoma
/ pathology
Osteosarcoma
/ pathology
Positron Emission Tomography Computed Tomography
/ methods
Radioisotopes
/ pharmacology
Radium
/ pharmacology
Sodium Fluoride
Alpha therapy
Entropy
Fluorine-18 isotopes
Osteosarcoma
Positron emission tomography
Radiomics
Radium-223 isotopes
Sodium fluoride PET
Journal
Current problems in cancer
ISSN: 1535-6345
Titre abrégé: Curr Probl Cancer
Pays: United States
ID NLM: 7702986
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
18
08
2021
accepted:
02
09
2021
pubmed:
29
10
2021
medline:
5
2
2022
entrez:
28
10
2021
Statut:
ppublish
Résumé
Patients with osteoblastic metastases from high risk osteosarcoma continue to have a poor prognosis after progression from standard-of-care multi-agent chemotherapy. In a first-in-human dose escalation trial of bone targeted Radium 223 dichloride alpha-particle therapy in 18 patients with advanced osteosarcoma only 1 patient responded based on conventional Response Evaluation Criteria in Solid Tumors (RECIST). Na
Identifiants
pubmed: 34706830
pii: S0147-0272(21)00114-8
doi: 10.1016/j.currproblcancer.2021.100797
pii:
doi:
Substances chimiques
Fluorine Radioisotopes
0
Radioisotopes
0
Sodium Fluoride
8ZYQ1474W7
Fluorine-18
GZ5I74KB8G
radium Ra 223 dichloride
RJ00KV3VTG
Radium
W90AYD6R3Q
Types de publication
Clinical Trial, Phase I
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100797Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.