Development of retinal bullae in dogs with progressive retinal atrophy.
BEST1
CNGB1
bullae
bullous retinal detachment
dog
progressive retinal atrophy
Journal
Veterinary ophthalmology
ISSN: 1463-5224
Titre abrégé: Vet Ophthalmol
Pays: England
ID NLM: 100887377
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
revised:
04
08
2021
received:
10
06
2021
accepted:
23
08
2021
pubmed:
29
10
2021
medline:
29
3
2022
entrez:
28
10
2021
Statut:
ppublish
Résumé
To report the development of focal bullous retinal detachments (bullae) in dogs with different forms of progressive retinal atrophy (PRA). Dogs with three distinct forms of PRA (PRA-affected Whippets, German Spitzes and CNGB1-mutant Papillon crosses) were examined by indirect ophthalmoscopy and spectral domain optical coherence tomography (SD-OCT). Retinal bullae were monitored over time. One CNGB1-mutant dog was treated with gene augmentation therapy. The canine BEST1 gene coding region and flanking intronic sequence was sequenced in at least one affected dog of each breed. Multiple focal bullous retinal detachments (bullae) were identified in PRA-affected dogs of all three types. They developed in 4 of 5 PRA-affected Whippets, 3 of 8 PRA-affected Germans Spitzes and 15 of 20 CNGB1-mutant dogs. The bullae appeared prior to marked retinal degeneration and became less apparent as retinal degeneration progressed. Bullae were not seen in any heterozygous animals of any of the types of PRA. Screening of the coding region and flanking intronic regions of the canine BEST1 gene failed to reveal any associated pathogenic variants. Retinal gene augmentation therapy in one of the CNGB1-mutant dogs appeared to prevent formation of bullae. Retinal bullae were identified in dogs with three distinct forms of progressive retinal atrophy. The lesions develop prior to retinal thinning. This clinical change should be monitored for in dogs with PRA.
Identifiants
pubmed: 34708922
doi: 10.1111/vop.12932
pmc: PMC10074838
mid: NIHMS1877027
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109-117Subventions
Organisme : Universidade do Parana
Organisme : NIH HHS
ID : R24EY027285
Pays : United States
Organisme : NEI NIH HHS
ID : R24 EY027285
Pays : United States
Organisme : Programa Institucional de Internacionalização - CAPES - PrInt
Organisme : Myers-Dunlap Endowment
Informations de copyright
© 2021 American College of Veterinary Ophthalmologists.
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