The RNA modification in Echinococcus granulosus cysts revealed by mass spectrometry.

Animals Chromatography, High Pressure Liquid Computational Biology Cysts / parasitology Echinococcus granulosus / genetics Mice RNA, Helminth / genetics Tandem Mass Spectrometry
Echinococcus granulosus Epigenetic Parasites RNA modification UPLC-MS/MS

Journal

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
ISSN: 1567-7257
Titre abrégé: Infect Genet Evol
Pays: Netherlands
ID NLM: 101084138

Informations de publication

Date de publication:
12 2021
Historique:
received: 01 08 2021
revised: 29 09 2021
accepted: 22 10 2021
pubmed: 29 10 2021
medline: 14 1 2022
entrez: 28 10 2021
Statut: ppublish

Résumé

RNA modifications, as one of epigenetic mechanisms, are important and conserved mechanisms for maintaining the homeostasis of organisms. Little is known about RNA modifications in Echinococcus granulosus, an obligate parasite that inhabits mammals and gives rise to a huge public health and economic impact. Here, we focused on the RNA modification characteristics of E. granulosus for the first time by using mass spectrometry (UPLC-MS/MS) to qualitatively and quantitatively analyze 47 types of RNA modifications in E. granulosus total RNA. Furthermore, the E. granulosus homologs of writer enzymes preforming RNA modifications were identified, and their gene expression pattern at different developmental stages were analyzed by bioinformatics analysis. Finally, 23 types of RNA modifications were found in E. granulosus cysts total RNA, of which m

Identifiants

DOI: 10.1016/j.meegid.2021.105124 PMID: 34710588
pubmed: 34710588
pii: S1567-1348(21)00424-X
doi: 10.1016/j.meegid.2021.105124
pii:
doi:

Substances chimiques

RNA, Helminth 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

105124

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

Congshan Liu (C)

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Center for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai, China.

Jianping Cao (J)

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Center for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai, China.

Haobing Zhang (H)

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Center for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai, China.

Jianhai Yin (J)

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Center for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai, China. Electronic address: yinjh@nipd.chinacdc.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The RNA modification in Echinococcus...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › The RNA modification in Echinococcus...
questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › The RNA modification in Echinococcus...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Kystes › The RNA modification in Echinococcus...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Plathelminthes › Cestoda › Echinococcus › Echinococcus granulosus › The RNA modification in Echinococcus...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The RNA modification in Echinococcus...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN des helminthes › The RNA modification in Echinococcus...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › The RNA modification in Echinococcus...