Determinants of prognosis in patients with oral squamous cell carcinoma metastasizing to a single cervical lymph node.
Node positive neck
Oral cancer
Pathologic risk factors
Prognostic factors
Single positive node
Journal
Oral oncology
ISSN: 1879-0593
Titre abrégé: Oral Oncol
Pays: England
ID NLM: 9709118
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
17
05
2021
revised:
17
06
2021
accepted:
15
10
2021
pubmed:
29
10
2021
medline:
11
3
2022
entrez:
28
10
2021
Statut:
ppublish
Résumé
Metastasis in a single lymph node without adverse tumour factors and perineural invasion has been assigned to a lower risk category by the ASCO recommendations of 2019. We analyzed patients with a single positive node with a view to identifying high risk features and their impact on prognosis within this subgroup. The study retrospectively analyzed 707 patients with OSCC. Descriptive statistics were used to compare distribution of clinicopathologic risk features between 323 N0 and 121 single node positive (N The N Significant differences are noted in the prevalence of pathologic risk factors between the single node positive and node negative groups. Within the single node positive group, tumour factors like the gingivobuccal subsite, PNI and margin positivity impacted survival. Among nodal factors, deposit size of 12 mm or more and presence of ENE are pointers to poor prognosis. These patients would benefit from adjuvant treatment.
Identifiants
pubmed: 34710734
pii: S1368-8375(21)00693-X
doi: 10.1016/j.oraloncology.2021.105586
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105586Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.