Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines.
Journal
NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863
Informations de publication
Date de publication:
28 Oct 2021
28 Oct 2021
Historique:
received:
19
07
2021
accepted:
01
10
2021
entrez:
29
10
2021
pubmed:
30
10
2021
medline:
30
10
2021
Statut:
epublish
Résumé
Toll-like receptors (TLRs) are transmembrane proteins belonging to the family of pattern-recognition receptors. They function as sensors of invading pathogens through recognition of pathogen-associated molecular patterns. After their engagement by microbial ligands, TLRs trigger downstream signaling pathways that culminate into transcriptional upregulation of genes involved in immune defense. Here we provide an updated overview on members of the TLR family and we focus on their role in antiviral response. Understanding of innate sensing and signaling of viruses triggered by these receptors would provide useful knowledge to prompt the development of vaccines able to elicit effective and long-lasting immune responses. We describe the mechanisms developed by viral pathogens to escape from immune surveillance mediated by TLRs and finally discuss how TLR/virus interplay might be exploited to guide the design of innovative vaccine platforms.
Identifiants
pubmed: 34711839
doi: 10.1038/s41541-021-00391-8
pii: 10.1038/s41541-021-00391-8
pmc: PMC8553822
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
127Informations de copyright
© 2021. The Author(s).
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