A case-control study in Taiwanese cohort and meta-analysis of serum ferritin in pancreatic cancer.
Biomarkers
Case-Control Studies
Computational Biology
/ methods
Disease Susceptibility
Ferritins
/ blood
Ferroptosis
/ genetics
Gene Expression Profiling
Gene Expression Regulation
Humans
Iron
/ metabolism
Pancreatic Neoplasms
/ blood
Public Health Surveillance
Risk Factors
Taiwan
/ epidemiology
Transcriptome
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 10 2021
28 10 2021
Historique:
received:
19
04
2021
accepted:
06
10
2021
entrez:
29
10
2021
pubmed:
30
10
2021
medline:
28
1
2022
Statut:
epublish
Résumé
Pancreatic cancer is one of the most lethal diseases which lack an early diagnostic marker. We investigated whether serum ferritin (SF) reflects risk for pancreatic cancer and potential genes that may contribute ferritin and pancreatic cancer risks. We performed a meta-analysis of relevant studies on SF and pancreatic cancer risk by searching articles in PUBMED and EMBASE published up to 1 March 2020. We also collected serum samples from Taipei Medical University Joint Biobank and compared SF levels in 34 healthy controls and 34 pancreatic cancer patients. An Oncomine database was applied as a platform to explore a series of genes that exhibited strong associations between ferritin and pancreatic cancer. Herein, we show that high levels of SF can indicate risk of pancreatic cancer, suggesting SF as the new tumor marker that may be used to help pancreatic cancer diagnosis. We also found that expressions of iron homeostasis genes (MYC, FXN) and ferroptosis genes (ALOX15, CBS, FDFT1, LPCAT3, RPL8, TP53, TTC35) are significantly altered with pancreatic tumor grades, which may contribute to differential expression of ferritin related to pancreatic cancer prognosis.
Identifiants
pubmed: 34711879
doi: 10.1038/s41598-021-00650-7
pii: 10.1038/s41598-021-00650-7
pmc: PMC8553768
doi:
Substances chimiques
Biomarkers
0
Ferritins
9007-73-2
Iron
E1UOL152H7
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
21242Informations de copyright
© 2021. The Author(s).
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