Retinal Oxygen Metabolism and Haemodynamics in Patients With Multiple Sclerosis and History of Optic Neuritis.
microcirculation
multiple sclerosis
optical coherence tomography angiography
retinal blood flow
retinal oxygen saturation
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2021
2021
Historique:
received:
20
08
2021
accepted:
22
09
2021
entrez:
29
10
2021
pubmed:
30
10
2021
medline:
30
10
2021
Statut:
epublish
Résumé
Vascular changes and alterations of oxygen metabolism are suggested to be implicated in multiple sclerosis (MS) pathogenesis and progression. Recently developed in vivo retinal fundus imaging technologies provide now an opportunity to non-invasively assess metabolic changes in the neural retina. This study was performed to assess retinal oxygen metabolism, peripapillary capillary density (CD), large vessel density (LVD), retinal nerve fiber layer thickness (RNFLT) and ganglion cell inner plexiform layer thickness (GCIPLT) in patients with diagnosed relapsing multiple sclerosis (RMS) and history of unilateral optic neuritis (ON). 16 RMS patients and 18 healthy controls (HC) were included in this study. Retinal oxygen extraction was modeled using O
Identifiants
pubmed: 34712117
doi: 10.3389/fnins.2021.761654
pmc: PMC8546107
doi:
Banques de données
ClinicalTrials.gov
['NCT03401879']
Types de publication
Journal Article
Langues
eng
Pagination
761654Informations de copyright
Copyright © 2021 Kallab, Hommer, Schlatter, Bsteh, Altmann, Popa-Cherecheanu, Pfister, Werkmeister, Schmidl, Schmetterer and Garhöfer.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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