The TNF-α/TNFR2 Pathway: Targeting a Brake to Release the Anti-tumor Immune Response.
anti-tumor action
cancer
immunosuppression
immunotherapies
regulatory T cells (Tregs)
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
06
2021
accepted:
24
09
2021
entrez:
29
10
2021
pubmed:
30
10
2021
medline:
30
10
2021
Statut:
epublish
Résumé
Newly discovered anti-cancer immunotherapies, such as immune checkpoint inhibitors and chimeric antigen receptor T cells, focus on spurring the anti-tumor effector T cell (Teff) response. Although such strategies have already demonstrated a sustained beneficial effect in certain malignancies, a substantial proportion of treated patients does not respond. CD4
Identifiants
pubmed: 34712661
doi: 10.3389/fcell.2021.725473
pmc: PMC8546260
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
725473Informations de copyright
Copyright © 2021 Moatti and Cohen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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