Monoclonal Antibodies for Protozoan Infections: A Future Reality or a Utopic Idea?
Chagas disease
leishmaniasis
malaria
monoclonal antibody
protozoa
toxoplasmosis
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
07
2021
accepted:
17
09
2021
entrez:
29
10
2021
pubmed:
30
10
2021
medline:
30
10
2021
Statut:
epublish
Résumé
Following the SARS-CoV-2 pandemic, several clinical trials have been approved for the investigation of the possible use of mAbs, supporting the potential of this technology as a therapeutic approach for infectious diseases. The first monoclonal antibody (mAb), Muromonab CD3, was introduced for the prevention of kidney transplant rejection more than 30 years ago; since then more than 100 mAbs have been approved for therapeutic purposes. Nonetheless, only four mAbs are currently employed for infectious diseases: Palivizumab, for the prevention of respiratory syncytial virus (RSV) infections, Raxibacumab and Obiltoxaximab, for the prophylaxis and treatment against anthrax toxin and Bezlotoxumab, for the prevention of
Identifiants
pubmed: 34712683
doi: 10.3389/fmed.2021.745665
pmc: PMC8545981
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
745665Informations de copyright
Copyright © 2021 Longoni, Tiberti, Bisoffi and Piubelli.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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