Fluorescence-Based Quantitative and Spatial Analysis of Tumour Spheroids: A Proposed Tool to Predict Patient-Specific Therapy Response.
anti-cancer drug response
cell death
hypoxia
immune cell infiltration
intra-tumoural heterogeneity
spatial analysis
tumour micro-environment
tumour spheroid
Journal
Frontiers in digital health
ISSN: 2673-253X
Titre abrégé: Front Digit Health
Pays: Switzerland
ID NLM: 101771889
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
02
2021
accepted:
22
04
2021
entrez:
29
10
2021
pubmed:
30
10
2021
medline:
30
10
2021
Statut:
epublish
Résumé
Tumour spheroids are widely used to pre-clinically assess anti-cancer treatments. They are an excellent compromise between the lack of microenvironment encountered in adherent cell culture conditions and the great complexity of
Identifiants
pubmed: 34713141
doi: 10.3389/fdgth.2021.668390
pmc: PMC8521823
doi:
Types de publication
Journal Article
Langues
eng
Pagination
668390Informations de copyright
Copyright © 2021 Spoerri, Gunasingh and Haass.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cell Death Dis. 2019 Apr 24;10(5):342
pubmed: 31019203
Cell. 2008 Feb 8;132(3):487-98
pubmed: 18267078
Methods Mol Biol. 2017;1612:401-416
pubmed: 28634959
Clin Cancer Res. 2008 Mar 15;14(6):1649-57
pubmed: 18347166
Exp Dermatol. 2017 Jul;26(7):649-655
pubmed: 28109167
Expert Opin Drug Discov. 2008 Jan;3(1):1-10
pubmed: 23480136
J Invest Dermatol. 2016 Jul;136(7):1479-1489
pubmed: 26970356
Cell Signal. 2013 Jan;25(1):308-18
pubmed: 23079083
Br J Cancer. 2016 May 10;114(10):1071-7
pubmed: 27070712
Int J Radiat Oncol Biol Phys. 2017 Aug 1;98(5):1183-1196
pubmed: 28721903
Cancer Sci. 2010 Jun;101(6):1403-8
pubmed: 20367638
Clin Cancer Res. 2003 Mar;9(3):1145-54
pubmed: 12631620
J Vis Exp. 2015 Dec 28;(106):e53486
pubmed: 26779761
Front Oncol. 2018 May 24;8:173
pubmed: 29881716
Pigment Cell Melanoma Res. 2014 Sep;27(5):764-76
pubmed: 24902993
Mol Pharm. 2011 Dec 5;8(6):2039-49
pubmed: 22067046
J Clin Oncol. 2011 Aug 1;29(22):3085-96
pubmed: 21383288
Cancer Discov. 2021 Apr;11(4):874-899
pubmed: 33811122
Am Soc Clin Oncol Educ Book. 2020 May;40:e275-e291
pubmed: 32453632
Nature. 2014 Nov 27;515(7528):568-71
pubmed: 25428505
Adv Healthc Mater. 2017 Jul;6(13):
pubmed: 28557249
JAMA Netw Open. 2019 May 3;2(5):e192535
pubmed: 31050774
Mol Cancer. 2019 Nov 11;18(1):157
pubmed: 31711497
Melanoma Manag. 2014 Nov;1(2):127-137
pubmed: 30190818
Healthcare (Basel). 2013 Dec 23;2(1):27-46
pubmed: 27429258
Nat Rev Clin Oncol. 2019 Sep;16(9):563-580
pubmed: 31092901
Lancet. 2010 Jul 24;376(9737):245-51
pubmed: 20609468