Distinct Aβ pathology in the olfactory bulb and olfactory deficits in a mouse model of Aβ and α-syn co-pathology.
Alzheimer's disease
Aβ seeding
amyloid-β plaques
dementia with Lewy bodies
olfaction
olfactory bulb
α-synuclein
Journal
Brain pathology (Zurich, Switzerland)
ISSN: 1750-3639
Titre abrégé: Brain Pathol
Pays: Switzerland
ID NLM: 9216781
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
27
09
2021
received:
10
08
2021
accepted:
29
09
2021
pubmed:
30
10
2021
medline:
3
5
2022
entrez:
29
10
2021
Statut:
ppublish
Résumé
Several degenerative brain disorders such as Alzheimer's disease (AD), Parkinson's disease (PD) and Dementia with Lewy bodies (DLB) are characterized by the simultaneous appearance of amyloid-β (Aβ) and α-synuclein (α-syn) pathologies and symptoms that are similar, making it difficult to differentiate between these diseases. Until now, an accurate diagnosis can only be made by postmortem analysis. Furthermore, the role of α-syn in Aβ aggregation and the arising characteristic olfactory impairments observed during the progression of these diseases is still not well understood. Therefore, we assessed Aβ load in olfactory bulbs of APP-transgenic mice expressing APP695
Identifiants
pubmed: 34713522
doi: 10.1111/bpa.13032
pmc: PMC9048518
doi:
Substances chimiques
Amyloid beta-Peptides
0
alpha-Synuclein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13032Informations de copyright
© 2021 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.
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