Druggable Allosteric Sites in β-Propeller Lectins.
NMR spectroscopy
allostery
carbohydrate-protein interactions
drug discovery
fragment-based drug design
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
03 01 2022
03 01 2022
Historique:
revised:
05
10
2021
received:
13
07
2021
pubmed:
30
10
2021
medline:
18
1
2022
entrez:
29
10
2021
Statut:
ppublish
Résumé
Carbohydrate-binding proteins (lectins) are auspicious targets in drug discovery to combat antimicrobial resistance; however, their non-carbohydrate drug-like inhibitors are still unavailable. Here, we present a druggable pocket in a β-propeller lectin BambL from Burkholderia ambifaria as a potential target for allosteric inhibitors. This site was identified employing
Identifiants
pubmed: 34713573
doi: 10.1002/anie.202109339
pmc: PMC9298952
doi:
Substances chimiques
Lectins
0
Small Molecule Libraries
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202109339Subventions
Organisme : deutsche forschungsgemeinschaft
ID : RA1944/7-1
Organisme : agence nationale de la recherche
ID : ANR-17-CE11-0048
Organisme : agence nationale de la recherche
ID : ANR-15-IDEX-02
Organisme : agence nationale de la recherche
ID : ANR-17-EURE-0003
Organisme : horizon 2020 framework programme
ID : MSCA 76558
Informations de copyright
© 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
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