Vaccine development and technology for SARS-CoV-2: Current insight.
SARS-CoV-2
lipid nanoparticles
pandemic
pneumonia
vaccine
viral vector
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
revised:
23
02
2021
received:
29
05
2021
accepted:
26
10
2021
pubmed:
30
10
2021
medline:
7
6
2022
entrez:
29
10
2021
Statut:
ppublish
Résumé
Severe acute respiratory syndrome coronavirus 2 is associated with a severe respiratory disease in China, that rapidly spread across continents. Since the beginning of the pandemic, available data suggested the asymptomatic transmission and patients were treated with specific drugs with efficacy and safety data not always satisfactory. The aim of this review is to describe the vaccines developed by three companies, Pfizer-BioNTech, Moderna, and University of Oxford/AstraZeneca, in terms of both technological and pharmaceutical formulation, safety, efficacy, and immunogenicity. A critical analysis of Phases 1, 2, and 3 clinical trial results available was conducted, comparing the three vaccine candidates, underlining their similarities and differences. All candidates showed consistent efficacy and tolerability; although some differences can be noted, such as their technological formulation, temperature storage, which will be related to logistics and costs. Further studies will be necessary to evaluate long-term effects and to assess the vaccine safety and efficacy in the general population.
Identifiants
pubmed: 34713912
doi: 10.1002/jmv.27425
pmc: PMC8662109
doi:
Substances chimiques
COVID-19 Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
878-896Informations de copyright
© 2021 Wiley Periodicals LLC.
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