A 13-Year National Monitoring Study to Assess Narcotic Prescriptions and Indications (2007-2019).


Journal

Drug safety
ISSN: 1179-1942
Titre abrégé: Drug Saf
Pays: New Zealand
ID NLM: 9002928

Informations de publication

Date de publication:
01 2022
Historique:
accepted: 21 09 2021
pubmed: 30 10 2021
medline: 22 4 2022
entrez: 29 10 2021
Statut: ppublish

Résumé

Analgesics are among the most widely used drugs worldwide. This study describes the population treated with narcotic analgesics, their therapeutic indications and how the data have evolved over a decade. A cross-sectional, national, multicentre survey study was conducted that included surveys taken every year from 2007 to 2019 in a national sample of 1500 randomly selected dispensing pharmacies. The mean age of patients, mostly women (around 60%), remained stable over the study period (63.2 ± 17.1 years in 2007, 68.2 ± 17.2 years in 2019). The proportion of patients treated for more than 3 months increased from 2007 to 2019. Most prescriptions involved morphine, oxycodone and fentanyl (98.5% of all prescriptions in 2019). Morphine prescriptions dropped dramatically from 49.6% (2007) to 32.3% (2019) of the total narcotic analgesics. Fentanyl prescriptions varied from 40.1% in 2007 to 32.2% in 2019. Prescriptions of oxycodone, regardless of the indication, increased steadily from 2007, from 8.3 to 34% in 2019, becoming the most prescribed narcotic analgesic for the first time since the beginning of the survey. This study demonstrates how narcotic opioids are prescribed, thanks to the active participation of health professionals, and confirms the striking increase in the prescription of oxycodone.

Identifiants

pubmed: 34714529
doi: 10.1007/s40264-021-01124-5
pii: 10.1007/s40264-021-01124-5
doi:

Substances chimiques

Analgesics, Opioid 0
Narcotics 0
Morphine 76I7G6D29C
Oxycodone CD35PMG570
Fentanyl UF599785JZ

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

37-44

Investigateurs

Nathalie Fouilhé (N)
Alexandra Boucher (A)
Stéphanie Pain (S)
Samira Djezzar (S)
Hélène Peyrière (H)
Marie Gérardin (M)
Christine Fournier-Choma (C)
Valérie Gibaja (V)
Reynald Boisselier (R)
Anne-Sylvie Caous (AS)

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

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Auteurs

Joelle Perri-Plandé (J)

Centre d'addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, Hôpital Pellegrin, CHU, 33076, Bordeaux Cedex, France.

Ghada Miremont-Salamé (G)

Centre d'addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, Hôpital Pellegrin, CHU, 33076, Bordeaux Cedex, France.
Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Team, Pharmacoepidemiology, UMR 1219, Bordeaux, France.

Joëlle Micallef (J)

Aix Marseille Univ, AP-HM, INSERM, Inst Neurosci Syst, Service de Pharmacologie Clinique et Pharmacovigilance, Marseille, France.

Cameron Herman (C)

Centre d'addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, Hôpital Pellegrin, CHU, 33076, Bordeaux Cedex, France.

Marie Baumevieille (M)

Centre d'addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, Hôpital Pellegrin, CHU, 33076, Bordeaux Cedex, France.
Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Team, Pharmacoepidemiology, UMR 1219, Bordeaux, France.

Frédéric Abriat (F)

Centre d'addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, Hôpital Pellegrin, CHU, 33076, Bordeaux Cedex, France.

Maryse Lapeyre-Mestre (M)

Centre d'Addictovigilance, CHU, UMR-INSERM 1027, Toulouse, France.

Françoise Haramburu (F)

Centre d'addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, Hôpital Pellegrin, CHU, 33076, Bordeaux Cedex, France.
Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Team, Pharmacoepidemiology, UMR 1219, Bordeaux, France.

Amélie Daveluy (A)

Centre d'addictovigilance, Service de pharmacologie médicale, CHU Bordeaux, Hôpital Pellegrin, CHU, 33076, Bordeaux Cedex, France. amelie.daveluy@u-bordeaux.fr.
Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Team, Pharmacoepidemiology, UMR 1219, Bordeaux, France. amelie.daveluy@u-bordeaux.fr.

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