Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain-like Protease PL
PLpro
SARS-CoV-2
gold, metallodrugs
polyoxometalates
silver
spike protein
titanocene
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
20 Dec 2021
20 Dec 2021
Historique:
received:
08
09
2021
pubmed:
30
10
2021
medline:
22
12
2021
entrez:
29
10
2021
Statut:
ppublish
Résumé
The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has called for an urgent need for dedicated antiviral therapeutics. Metal complexes are commonly underrepresented in compound libraries that are used for screening in drug discovery campaigns, however, there is growing evidence for their role in medicinal chemistry. Based on previous results, we have selected more than 100 structurally diverse metal complexes for profiling as inhibitors of two relevant SARS-CoV-2 replication mechanisms, namely the interaction of the spike (S) protein with the ACE2 receptor and the papain-like protease PL
Identifiants
pubmed: 34714566
doi: 10.1002/chem.202103258
pmc: PMC8653295
doi:
Substances chimiques
Antiviral Agents
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Coronavirus Papain-Like Proteases
EC 3.4.22.2
papain-like protease, SARS-CoV-2
EC 3.4.22.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
17928-17940Subventions
Organisme : European Research Council
Pays : International
Informations de copyright
© 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.
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