Memantine improves cognitive deficits via K

Adenosine Triphosphate Animals Cognition Hippocampus Humans Long-Term Potentiation Memantine / pharmacology Mice Olfactory Bulb / surgery
CaMKII CaMKIV Cognitive deficits K(ATP) channel Memantine OBX mice

Journal

Molecular and cellular neurosciences
ISSN: 1095-9327
Titre abrégé: Mol Cell Neurosci
Pays: United States
ID NLM: 9100095

Informations de publication

Date de publication:
12 2021
Historique:
received: 19 03 2021
revised: 20 10 2021
accepted: 21 10 2021
pubmed: 30 10 2021
medline: 14 1 2022
entrez: 29 10 2021
Statut: ppublish

Résumé

Patients with Alzheimer's disease (AD) demonstrate severely impaired olfactory systems, which occur in the early stages of the disease. Olfactory bulbectomy (OBX) in mice elicits cognitive deficits, and reduces cholinergic activity in the hippocampus. Here, we confirmed that the novel AD drug memantine rescues cognitive deficits via ATP-sensitive potassium (K

Identifiants

DOI: 10.1016/j.mcn.2021.103680 PMID: 34715352
pubmed: 34715352
pii: S1044-7431(21)00093-2
doi: 10.1016/j.mcn.2021.103680
pii:
doi:

Substances chimiques

Adenosine Triphosphate 8L70Q75FXE
Memantine W8O17SJF3T

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103680

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Shigeki Moriguchi (S)

Research Center for Pharmaceutical Development, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. Electronic address: shigeki.moriguchi.a3@tohoku.ac.jp.

Ryo Inagaki (R)

Research Center for Pharmaceutical Development, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

Kohji Fukunaga (K)

Department of CNS Drug Innovation, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Memantine improves cognitive deficits via K
questionsmedicales.fr › Eucaryotes › Animaux › Memantine improves cognitive deficits via K
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Memantine improves cognitive deficits via K
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Memantine improves cognitive deficits via K
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Memantine improves cognitive deficits via K
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Potentialisation à long terme › Memantine improves cognitive deficits via K
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Amantadine › Mémantine › Memantine improves cognitive deficits via K
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Memantine improves cognitive deficits via K
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Bulbe olfactif › Memantine improves cognitive deficits via K