The envelope protein of Usutu virus attenuates West Nile virus virulence in immunocompetent mice.

5' Untranslated Regions Animals Flavivirus / genetics Genome, Viral Mice Virulence West Nile Fever / prevention & control West Nile virus / genetics
Chimeric WNV/USUV Genome manipulation Mice Reverse genetics

Journal

Veterinary microbiology
ISSN: 1873-2542
Titre abrégé: Vet Microbiol
Pays: Netherlands
ID NLM: 7705469

Informations de publication

Date de publication:
Dec 2021
Historique:
received: 14 08 2020
accepted: 17 10 2021
pubmed: 30 10 2021
medline: 15 12 2021
entrez: 29 10 2021
Statut: ppublish

Résumé

West Nile virus (WNV) and Usutu virus (USUV) are the two most widespread mosquito-borne flaviviruses in Europe causing severe neuroinvasive disease in humans. Here, following standardization of the murine model with wild type (wt) viruses, we engineered WNV and USUV genome by reverse genetics. A recombinant virus carrying the 5' UTR of WNV within the USUV genome backbone (r-USUV

Identifiants

DOI: 10.1016/j.vetmic.2021.109262 PMID: 34715462
pubmed: 34715462
pii: S0378-1135(21)00285-6
doi: 10.1016/j.vetmic.2021.109262
pii:
doi:

Substances chimiques

5' Untranslated Regions 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109262

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Auteurs

Guendalina Zaccaria (G)

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise (IZSAM), Campo Boario, 64100 Teramo, Italy.

Daniela Malatesta (D)

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise (IZSAM), Campo Boario, 64100 Teramo, Italy.

Lucija Jurisic (L)

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise (IZSAM), Campo Boario, 64100 Teramo, Italy; Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.

Maurilia Marcacci (M)

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise (IZSAM), Campo Boario, 64100 Teramo, Italy; Dipartimento di Medicina Veterinaria, University of Bari, Valenzano, Bari, Italy.

Giovanni Di Teodoro (G)

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise (IZSAM), Campo Boario, 64100 Teramo, Italy.

Annamaria Conte (A)

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise (IZSAM), Campo Boario, 64100 Teramo, Italy.

Liana Teodori (L)

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise (IZSAM), Campo Boario, 64100 Teramo, Italy.

Federica Monaco (F)

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise (IZSAM), Campo Boario, 64100 Teramo, Italy.

Valeria Marini (V)

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise (IZSAM), Campo Boario, 64100 Teramo, Italy.

Claudia Casaccia (C)

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise (IZSAM), Campo Boario, 64100 Teramo, Italy.

Giovanni Savini (G)

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise (IZSAM), Campo Boario, 64100 Teramo, Italy.

Annapia Di Gennaro (A)

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise (IZSAM), Campo Boario, 64100 Teramo, Italy.

Emanuela Rossi (E)

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise (IZSAM), Campo Boario, 64100 Teramo, Italy.

Vincenzo D'Innocenzo (V)

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise (IZSAM), Campo Boario, 64100 Teramo, Italy.

Nicola D'Alterio (N)

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise (IZSAM), Campo Boario, 64100 Teramo, Italy.

Alessio Lorusso (A)

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise (IZSAM), Campo Boario, 64100 Teramo, Italy. Electronic address: a.lorusso@izs.it.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Régions non traduites › Régions 5' non traduites › The envelope protein of Usutu virus attenuates...
questionsmedicales.fr › Eucaryotes › Animaux › The envelope protein of Usutu virus attenuates...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Flaviviridae › Flavivirus › The envelope protein of Usutu virus attenuates...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome viral › The envelope protein of Usutu virus attenuates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The envelope protein of Usutu virus attenuates...
questionsmedicales.fr › Phénomènes microbiologiques › Virulence › The envelope protein of Usutu virus attenuates...
questionsmedicales.fr › Maladies du système nerveux › Encéphalite › Encéphalite infectieuse › Encéphalite virale › Encéphalite à arbovirus › Fièvre à virus West Nile › The envelope protein of Usutu virus attenuates...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Flaviviridae › Flavivirus › Virus de l'encéphalite japonaise (sous-groupe) › Virus du Nil occidental › The envelope protein of Usutu virus attenuates...