Discovery of novel, potent and orally efficacious inhibitor of neutral amino acid transporter B

Amino Acid Transport Systems, Neutral / antagonists & inhibitors Animals Anti-Inflammatory Agents, Non-Steroidal / chemistry Dose-Response Relationship, Drug Drug Discovery Mice Mice, Inbred C57BL Molecular Structure Structure-Activity Relationship Sulfonamides / chemistry
B(0)AT1 Nimesulide Nitro group Trifluoromethyl sulfonyl

Journal

Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377

Informations de publication

Date de publication:
01 12 2021
Historique:
received: 12 08 2021
revised: 01 10 2021
accepted: 19 10 2021
pubmed: 1 11 2021
medline: 19 1 2022
entrez: 31 10 2021
Statut: ppublish

Résumé

Amino acid restriction by inhibition of neutral amino acid transporter, B

Identifiants

DOI: 10.1016/j.bmcl.2021.128421 PMID: 34718128
pubmed: 34718128
pii: S0960-894X(21)00648-X
doi: 10.1016/j.bmcl.2021.128421
pii:
doi:

Substances chimiques

Amino Acid Transport Systems, Neutral 0
Anti-Inflammatory Agents, Non-Steroidal 0
SLC6A19 protein, mouse 0
Sulfonamides 0
nimesulide V4TKW1454M

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

128421

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Jigar Desai (J)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India. Electronic address: jigardesai@zyduscadila.com.

Bhaumin Patel (B)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Brijesh Darji (B)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Archana Gite (A)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Nandini Panchal (N)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Gokul Bhosale (G)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Sandeep Shedage (S)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Sandip Patel (S)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Pravin Kadam (P)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Gautam Patel (G)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Brijesh Kumar Srivastava (B)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Amit Joharapurkar (A)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Samadhan Kshirsagar (S)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Poonam Giri (P)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Hitesh Bhayani (H)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Ankit Patel (A)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Krishnarup Ghoshdastidar (K)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Debdutta Bandyopadhyay (D)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Sanjay Kumar (S)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Mukul Jain (M)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India.

Rajiv Sharma (R)

Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India. Electronic address: Rajiv.Sharma@zyduscadila.com.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Systèmes de transport d'acides aminés › Systèmes de transport d'acides aminés neutres › Discovery of novel, potent and orally...
questionsmedicales.fr › Eucaryotes › Animaux › Discovery of novel, potent and orally...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antirhumatismaux › Anti-inflammatoires non stéroïdiens › Discovery of novel, potent and orally...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Discovery of novel, potent and orally...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Discovery of novel, potent and orally...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Discovery of novel, potent and orally...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Discovery of novel, potent and orally...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Discovery of novel, potent and orally...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Discovery of novel, potent and orally...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Discovery of novel, potent and orally...