Amino Acid Homeostasis in Mammalian Cells with a Focus on Amino Acid Transport.
ATF4
GCN2
autophagy
mTORC1
solute carrier
transceptor
Journal
The Journal of nutrition
ISSN: 1541-6100
Titre abrégé: J Nutr
Pays: United States
ID NLM: 0404243
Informations de publication
Date de publication:
11 01 2022
11 01 2022
Historique:
received:
17
08
2021
revised:
02
09
2021
accepted:
17
09
2021
pubmed:
1
11
2021
medline:
22
2
2022
entrez:
31
10
2021
Statut:
ppublish
Résumé
Amino acid homeostasis is maintained by import, export, oxidation, and synthesis of nonessential amino acids, and by the synthesis and breakdown of protein. These processes work in conjunction with regulatory elements that sense amino acids or their metabolites. During and after nutrient intake, amino acid homeostasis is dominated by autoregulatory processes such as transport and oxidation of excess amino acids. Amino acid deprivation triggers processes such as autophagy and the execution of broader transcriptional programs to maintain plasma amino acid concentrations. Amino acid transport plays a crucial role in the absorption of amino acids in the intestine, the distribution of amino acids across cells and organs, the recycling of amino acids in the kidney, and the recycling of amino acids after protein breakdown.
Identifiants
pubmed: 34718668
pii: S0022-3166(22)00519-3
doi: 10.1093/jn/nxab342
pmc: PMC8754572
doi:
Substances chimiques
Amino Acids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16-28Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.
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