Injectable Nanocomposite Implants Reduce ROS Accumulation and Improve Heart Function after Infarction.
Animals
Animals, Newborn
Disease Models, Animal
Gold
Heart
/ drug effects
Hydrogels
/ administration & dosage
Injections
Male
Metal Nanoparticles
Mice
Mice, Inbred C57BL
Myocardial Infarction
/ drug therapy
Nanocomposites
/ administration & dosage
Prostheses and Implants
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species
/ metabolism
cardiac tissue engineering
gold nanoparticles
heart disease
hydrogel
myocardial infarction
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
05
08
2021
received:
07
07
2021
pubmed:
2
11
2021
medline:
17
3
2022
entrez:
1
11
2021
Statut:
ppublish
Résumé
In a myocardial infarction, blood supply to the left ventricle is abrogated due to blockage of one of the coronary arteries, leading to ischemia, which further triggers the generation of reactive oxygen species (ROS). These sequential processes eventually lead to the death of contractile cells and affect the integrity of blood vessels, resulting in the formation of scar tissue. A new heart therapy comprised of cardiac implants encapsulated within an injectable extracellular matrix-gold nanoparticle composite hydrogel is reported. The particles on the collagenous fibers within the hydrogel promote fast transfer of electrical signal between cardiac cells, leading to the functional assembly of the cardiac implants. The composite hydrogel is shown to absorb reactive oxygen species in vitro and in vivo in mice ischemia reperfusion model. The reduction in ROS levels preserve cardiac tissue morphology and blood vessel integrity, reduce the scar size and the inflammatory response, and significantly prevent the deterioration of heart function.
Identifiants
pubmed: 34719885
doi: 10.1002/advs.202102919
pmc: PMC8693049
doi:
Substances chimiques
Hydrogels
0
Reactive Oxygen Species
0
Gold
7440-57-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2102919Subventions
Organisme : Ministry of Science, Technology & Space, Israel for the Ze'ev Jabotinsky fellowship
Organisme : ERC Starting
ID : 637943
Organisme : Slezak Foundation, the Israeli Science Foundation
ID : 700/13
Organisme : Moxie Foundation
Informations de copyright
© 2021 The Authors. Advanced Science published by Wiley-VCH GmbH.
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