Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model.


Journal

American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226

Informations de publication

Date de publication:
01 12 2021
Historique:
pubmed: 2 11 2021
medline: 4 1 2022
entrez: 1 11 2021
Statut: ppublish

Résumé

Optimizing enteral nutrition for premature infants may help mitigate extrauterine growth restriction and adverse chronic health outcomes. Previously, we showed in neonatal pigs born at term that lean growth is enhanced by intermittent bolus compared with continuous feeding. The objective was to determine if prematurity impacts how body composition, muscle protein synthesis, and myonuclear accretion respond to feeding modality. Following preterm delivery, pigs were fed equivalent amounts of formula delivered either as intermittent boluses (INT;

Identifiants

pubmed: 34719946
doi: 10.1152/ajpendo.00236.2021
pmc: PMC8714968
doi:

Substances chimiques

Muscle Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

E737-E752

Subventions

Organisme : HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
ID : HD-099080
Organisme : NICHD NIH HHS
ID : R01 HD099080
Pays : United States
Organisme : HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
ID : HD-085573
Organisme : NICHD NIH HHS
ID : R01 HD072891
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD085573
Pays : United States
Organisme : HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
ID : HD-072891

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Auteurs

Marko Rudar (M)

United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Department of Animal Sciences, Auburn University, Auburn, Alabama.

Jane K Naberhuis (JK)

United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Agus Suryawan (A)

United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Hanh V Nguyen (HV)

United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Barbara Stoll (B)

United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Candace C Style (CC)

The Department of Pediatric Surgery, Nationwide Children's Hospital, Columbus, Ohio.

Mariatu A Verla (MA)

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.

Oluyinka O Olutoye (OO)

The Department of Pediatric Surgery, Nationwide Children's Hospital, Columbus, Ohio.

Douglas G Burrin (DG)

United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Marta L Fiorotto (ML)

United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Teresa A Davis (TA)

United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

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Classifications MeSH