Acute Myeloid Leukemia Epigenetic Immune Escape From Nature Killer Cells by ICAM-1.
AML
ICAM-1
NK
immune escape
methylation
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
08
2021
accepted:
27
09
2021
entrez:
1
11
2021
pubmed:
2
11
2021
medline:
2
11
2021
Statut:
epublish
Résumé
Acute myeloid leukemia (AML), a malignant disorder of hemopoietic stem cells. AML can escape immunosurveillance of natural killer (NK) by gene mutation, fusions, and epigenetic modification, while the mechanism is not clearly understood. Here we show that the expression of Intercellular adhesion molecule-1 (ICAM-1, CD54) is silenced in AML cells. Decitabine could upregulate ICAM-1 expression, which contributes to the NK-AML cell conjugates and helps NK cells kill AML cells. We also show that ICAM-1 high expression can reverse the AML immune evasion and activate NK cells function
Identifiants
pubmed: 34722306
doi: 10.3389/fonc.2021.751834
pmc: PMC8548470
doi:
Types de publication
Journal Article
Langues
eng
Pagination
751834Informations de copyright
Copyright © 2021 Xiao, Chen, Wang, Guan, Wang, Zhang, Wang, Wang and Yu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Oncoimmunology. 2018 Oct 31;8(2):e1539617
pubmed: 30713800
Nucleic Acids Res. 2017 Jul 3;45(W1):W98-W102
pubmed: 28407145
PLoS One. 2013 May 09;8(5):e62924
pubmed: 23671644
Trends Cancer. 2020 Jul;6(7):580-592
pubmed: 32610068
Clin Sci (Lond). 2020 Jan 31;134(2):261-271
pubmed: 31922199
Crit Rev Oncol Hematol. 2019 Aug;140:1-7
pubmed: 31153036
Blood Rev. 2019 Sep;37:100578
pubmed: 31109711
Nat Commun. 2018 Jan 16;9(1):248
pubmed: 29339738
Leuk Lymphoma. 2021 Apr;62(4):937-943
pubmed: 33225787
FEBS J. 2014 Feb;281(4):1123-31
pubmed: 24314118
Nat Rev Clin Oncol. 2016 May;13(5):305-18
pubmed: 26620272
Nat Commun. 2016 Apr 04;7:11154
pubmed: 27040177
Blood. 2013 Jan 17;121(3):499-509
pubmed: 23223432
Cancer. 2006 Apr 15;106(8):1794-803
pubmed: 16532500
Nat Genet. 2005 Mar;37(3):265-74
pubmed: 15723065
J Hematol Oncol. 2020 Dec 7;13(1):167
pubmed: 33287858
Thorax. 2020 Feb;75(2):176-179
pubmed: 31915308
J Infect Dis. 2020 Feb 18;221(5):830-840
pubmed: 31586389
J Natl Cancer Inst. 2013 Aug 21;105(16):1172-87
pubmed: 23852952
Leukemia. 2018 May;32(5):1094-1105
pubmed: 29487386
Nature. 1988 Feb 18;331(6157):624-7
pubmed: 3340213