Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19.
Immunology
Transcriptomics
Virology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
19 Nov 2021
19 Nov 2021
Historique:
received:
30
06
2021
revised:
03
09
2021
accepted:
19
10
2021
pubmed:
2
11
2021
medline:
2
11
2021
entrez:
1
11
2021
Statut:
ppublish
Résumé
In parasite and viral infections, aberrant B cell responses can suppress germinal center reactions thereby blunting long-lived memory and may provoke immunopathology including autoimmunity. Using COVID-19 as model, we set out to identify serological, cellular, and transcriptomic imprints of pathological responses linked to autoreactive B cells at single-cell resolution. We show that excessive plasmablast expansions are prognostically adverse and correlate with autoantibody production but do not hinder the formation of neutralizing antibodies. Although plasmablasts followed interleukin-4 (IL-4) and BAFF-driven developmental trajectories, were polyclonal, and not enriched in autoreactive B cells, we identified two memory populations (CD80
Identifiants
pubmed: 34723157
doi: 10.1016/j.isci.2021.103325
pii: S2589-0042(21)01294-3
pmc: PMC8536484
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103325Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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