Artemisinin Cocrystals for Bioavailability Enhancement. Part 1: Formulation Design and Role of the Polymeric Excipient.
1H NMR
artemisinin cocrystals
bioavailability
diffusion
diffusion-ordered spectroscopy (DOSY)
solubility
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
06 12 2021
06 12 2021
Historique:
pubmed:
2
11
2021
medline:
15
3
2022
entrez:
1
11
2021
Statut:
ppublish
Résumé
Artemisinin (ART) is a most promising antimalarial agent, which is both effective and well tolerated in patients, though it has therapeutic limitations due to its low solubility, bioavailability, and short half-life. The objective of this work was to explore the possibility of formulating ART cocrystals, i.e., artemisinin-orcinol (ART-ORC) and artemisinin-resorcinol (ART
Identifiants
pubmed: 34723557
doi: 10.1021/acs.molpharmaceut.1c00384
doi:
Substances chimiques
Artemisinins
0
Excipients
0
Polymers
0
artemisinin
9RMU91N5K2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM