Neuropeptide Y as a risk factor for cardiorenal disease and cognitive dysfunction in chronic kidney disease: translational opportunities and challenges.
CKD
cardiovascular
dialysis
hypertension
renin–angiotensin system
Journal
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
ISSN: 1460-2385
Titre abrégé: Nephrol Dial Transplant
Pays: England
ID NLM: 8706402
Informations de publication
Date de publication:
28 12 2021
28 12 2021
Historique:
received:
30
07
2021
pubmed:
2
11
2021
medline:
23
3
2022
entrez:
1
11
2021
Statut:
ppublish
Résumé
Neuropeptide Y (NPY) is a 36-amino-acid peptide member of a family also including peptide YY and pancreatic polypeptide, which are all ligands to Gi/Go coupled receptors. NPY regulates several fundamental biologic functions including appetite/satiety, sex and reproduction, learning and memory, cardiovascular and renal function and immune functions. The mesenteric circulation is a major source of NPY in the blood in man and this peptide is considered a key regulator of gut-brain cross talk. A progressive increase in circulating NPY accompanies the progression of chronic kidney disease (CKD) toward kidney failure and NPY robustly predicts cardiovascular events in this population. Furthermore, NPY is suspected as a possible player in accelerated cognitive function decline and dementia in patients with CKD and in dialysis patients. In theory, interfering with the NPY system has relevant potential for the treatment of diverse diseases from cardiovascular and renal diseases to diseases of the central nervous system. Pharmaceutical formulations for effective drug delivery and cost, as well as the complexity of diseases potentially addressable by NPY/NPY antagonists, have been a problem until now. This in part explains the slow progress of knowledge about the NPY system in the clinical arena. There is now renewed research interest in the NPY system in psychopharmacology and in pharmacology in general and new studies and a new breed of clinical trials may eventually bring the expected benefits in human health with drugs interfering with this system.
Identifiants
pubmed: 34724060
pii: 6415214
doi: 10.1093/ndt/gfab284
pmc: PMC8713155
doi:
Substances chimiques
Neuropeptide Y
0
Receptors, Neuropeptide Y
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
ii14-ii23Investigateurs
Giovambattista Capasso
(G)
Alexandre Andrade
(A)
Maie Bachmann
(M)
Inga Bumblyte
(I)
Adrian Constantin Covic
(AC)
Pilar Delgado
(P)
Nicole Endlich
(N)
Andreas Engvig
(A)
Denis Fouque
(D)
Casper Franssen
(C)
Sebastian Frische
(S)
Liliana Garneata
(L)
Loreto Gesualdo
(L)
Konstantinos Giannakou
(K)
Dimitrios Goumenos
(D)
Ayşe Tuğba Kartal
(AT)
Laila-Yasmin Mani
(LY)
Hans-Peter Marti
(HP)
Christopher Mayer
(C)
Rikke Nielsen
(R)
Vesna Pešić
(V)
Merita Rroji Molla
(M)
Giorgos Sakkas
(G)
Goce Spasovski
(G)
Kate Stevens
(K)
Evgueniy Vazelov
(E)
Davide Viggiano
(D)
Lefteris Zacharia
(L)
Ana Carina Ferreira
(AC)
Jolanta Malyszko
(J)
Ewout Hoorn
(E)
Andreja Figurek
(A)
Robert Unwin
(R)
Carsten Wagner
(C)
Christoph Wanner
(C)
Annette Bruchfeld
(A)
Marion Pepin
(M)
Andrzej Wiecek
(A)
Dorothea Nitsch
(D)
Ivo Fridolin
(I)
Gaye Hafez
(G)
Maria José Soler Romeo
(MJS)
Michelangela Barbieri
(M)
Bojan Batinić
(B)
Laura Carrasco
(L)
Sol Carriazo
(S)
Ron Gansevoort
(R)
Gianvito Martino
(G)
Francesco Mattace Raso
(FM)
Ionut Nistor
(I)
Alberto Ortiz
(A)
Giuseppe Paolisso
(G)
Daiva Rastenytė
(D)
Gabriel Stefan
(G)
Gioacchino Tedeschi
(G)
Ziad Massy
(Z)
Boris Bikbov
(B)
Karl Hans Endlich
(KH)
Olivier Godefroy
(O)
Jean-Marc Chillon
(JM)
Anastassia Kossioni
(A)
Justina Kurganaite
(J)
Norberto Perico
(N)
Giuseppe Remuzzi
(G)
Tomasz Grodzicki
(T)
Francesco Trepiccione
(F)
Carmine Zoccali
(C)
Mustafa Arici
(M)
Peter Blankestijn
(P)
Kai-Uwe Eckardt
(KU)
Danilo Fliser
(D)
Eugenio Gutiérrez Jiménez
(EG)
Maximilian Konig
(M)
Ivan Rychlik
(I)
Michela Deleidi
(M)
George Reusz
(G)
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the ERA.
Références
Atherosclerosis. 2001 Nov;159(1):145-51
pubmed: 11689216
Balkan Med J. 2013 Jun;30(2):147-50
pubmed: 25207091
Brain Neurosci Adv. 2018 Nov 22;2:2398212818812629
pubmed: 32166162
Hypertension. 1997 Jan;29(1 Pt 1):137-43
pubmed: 9039093
Sci Rep. 2017 Jul 28;7(1):6821
pubmed: 28754895
J Hypertens. 2019 Jul;37(7):1359-1365
pubmed: 30633126
Int J Mol Sci. 2017 Aug 02;18(8):
pubmed: 28767097
Exp Clin Endocrinol Diabetes. 2006 Apr;114(4):147-52
pubmed: 16705546
Arch Gen Psychiatry. 2002 Sep;59(9):825-31
pubmed: 12215082
Acta Physiol (Oxf). 2015 Mar;213(3):603-27
pubmed: 25545642
Curr Protein Pept Sci. 2019;20(7):750-758
pubmed: 30678628
Biochem Biophys Rep. 2019 Jul 19;19:100666
pubmed: 31384672
Clin Res Cardiol. 2015 Dec;104(12):1064-71
pubmed: 26008896
Nephrol Dial Transplant. 2010 Dec;25(12):3823-31
pubmed: 20829401
Front Physiol. 2018 Sep 19;9:1281
pubmed: 30283345
Front Endocrinol (Lausanne). 2013 Feb 04;4:5
pubmed: 23382728
Obesity (Silver Spring). 2011 Nov;19(11):2137-48
pubmed: 21546930
EMBO Mol Med. 2010 Nov;2(11):429-39
pubmed: 20972986
Nature. 2006 Dec 14;444(7121):854-9
pubmed: 17167473
Genomics. 2009 Mar;93(3):254-60
pubmed: 18977429
Atherosclerosis. 2014 Jul;235(1):196-203
pubmed: 24858338
Int J Epidemiol. 2003 Feb;32(1):1-22
pubmed: 12689998
Genomics. 1996 Dec 15;38(3):392-8
pubmed: 8975716
Cardiovasc Res. 2002 Mar;53(4):879-87
pubmed: 11922898
Cell Physiol Biochem. 2018;45(1):88-107
pubmed: 29310113
J Korean Med Sci. 2008 Dec;23(6):1027-32
pubmed: 19119448
Eur Neuropsychopharmacol. 2014 Aug;24(8):1298-302
pubmed: 24709141
Nature. 2008 Apr 24;452(7190):997-1001
pubmed: 18385673
Hypertension. 2002 Jul;40(1):41-6
pubmed: 12105136
Nature. 1996 Jul 11;382(6587):168-71
pubmed: 8700207
Disaster Med Public Health Prep. 2019 Aug;13(4):782-790
pubmed: 31057134
J Clin Endocrinol Metab. 2003 Jul;88(7):3278-83
pubmed: 12843176
J Hypertens. 2004 Jul;22(7):1277-81
pubmed: 15201542
Eur J Neurosci. 1997 Jun;9(6):1212-25
pubmed: 9215705
Neuropeptides. 2012 Dec;46(6):261-74
pubmed: 22979996
Clin J Am Soc Nephrol. 2011 Jun;6(6):1400-9
pubmed: 21566108
Arterioscler Thromb Vasc Biol. 2003 Jul 1;23(7):1204-10
pubmed: 12689918
J Neurosci Res. 2020 May;98(5):950-963
pubmed: 32048334
J Nutrigenet Nutrigenomics. 2016;9(5-6):213-221
pubmed: 27788523
Neuropeptides. 2016 Feb;55:79-89
pubmed: 26454711
Neuropeptides. 2004 Aug;38(4):141-51
pubmed: 15337367
Int J Neuropsychopharmacol. 2018 Jan 1;21(1):3-11
pubmed: 29186416
Front Immunol. 2020 Oct 06;11:580378
pubmed: 33123166
Br J Pharmacol. 2011 Jul;163(6):1170-202
pubmed: 21545413
N Engl J Med. 1999 Apr 29;340(17):1321-8
pubmed: 10219067
Peptides. 2001 Mar;22(3):295-307
pubmed: 11287083
PLoS Genet. 2009 Jan;5(1):e1000318
pubmed: 19119412
J Biol Chem. 1994 Jan 7;269(1):232-7
pubmed: 8276799
FEBS Lett. 1996 Feb 26;381(1-2):58-62
pubmed: 8641440
Nat Rev Nephrol. 2020 Aug;16(8):452-469
pubmed: 32235904
PLoS One. 2020 Apr 20;15(4):e0231627
pubmed: 32310977
J Alzheimers Dis. 2018;64(1):181-193
pubmed: 29865062
Curr Opin Nephrol Hypertens. 2005 Jan;14(1):25-32
pubmed: 15586012
Hypertension. 2018 Sep;72(3):712-719
pubmed: 29987109
Ann N Y Acad Sci. 1990;611:145-55
pubmed: 2248475
J Clin Endocrinol Metab. 2000 Jun;85(6):2266-9
pubmed: 10852461
Clin J Am Soc Nephrol. 2011 Nov;6(11):2620-7
pubmed: 21940841
J Biol Chem. 1993 Mar 25;268(9):6703-7
pubmed: 8095935
J Clin Invest. 2021 Feb 1;131(3):
pubmed: 33290282
Neurobiol Dis. 2016 Nov;95:210-24
pubmed: 27461050
Nat Commun. 2021 May 11;12(1):2622
pubmed: 33976180
J Am Coll Cardiol. 2012 Oct 23;60(17):1678-89
pubmed: 23021333
Exp Clin Endocrinol Diabetes. 2000;108(3):235-6
pubmed: 10926322
Nat Med. 2010 Feb;16(2):228-31
pubmed: 20081863
Exp Eye Res. 2013 Feb;107:32-6
pubmed: 23178872
Cell Mol Neurobiol. 2012 Jul;32(5):645-59
pubmed: 22271177
Neuropeptides. 2004 Aug;38(4):189-200
pubmed: 15337371
Biol Psychiatry. 2000 May 15;47(10):902-9
pubmed: 10807963
J Biol Chem. 1996 Nov 1;271(44):27776-81
pubmed: 8910373
Biomolecules. 2020 Aug 27;10(9):
pubmed: 32867327
J Clin Endocrinol Metab. 2000 Apr;85(4):1455-60
pubmed: 10770181
Cell Physiol Biochem. 2015;37(1):94-104
pubmed: 26303143
J Biol Chem. 1995 Dec 8;270(49):29123-8
pubmed: 7493937
Am J Kidney Dis. 2007 Oct;50(4):594-601
pubmed: 17900459
Gastroenterology. 1983 Dec;85(6):1411-25
pubmed: 6138294
Dement Geriatr Cogn Disord. 1997 Jul-Aug;8(4):232-9
pubmed: 9213068
Sci Rep. 2016 Jul 27;6:30499
pubmed: 27460913
J Hypertens. 2021 Mar 1;39(3):408-416
pubmed: 33031182
Int J Med Sci. 2021 Jan 1;18(1):18-28
pubmed: 33390770
PLoS Genet. 2017 May 10;13(5):e1006657
pubmed: 28489853
FASEB J. 2001 May;15(7):1242-4
pubmed: 11344101
Nutr Metab (Lond). 2014 Jun 10;11:27
pubmed: 24959194
N Engl J Med. 1999 Apr 29;340(17):1360-1
pubmed: 10219074
Nephrol Dial Transplant. 2018 Oct 1;33(10):1805-1812
pubmed: 29370406
Eur J Clin Nutr. 2007 Sep;61(9):1102-5
pubmed: 17268419
Eur J Pharmacol. 2016 Apr 5;776:64-70
pubmed: 26875634
Regul Pept. 2005 Feb 15;125(1-3):9-15
pubmed: 15582708
J Hypertens. 2003 Jul;21(7):1355-62
pubmed: 12817184
J Biol Chem. 2000 Nov 17;275(46):36043-8
pubmed: 10944518
J Cereb Blood Flow Metab. 2001 Jan;21(1):77-84
pubmed: 11149671
Adv Exp Med Biol. 2020;1237:37-47
pubmed: 31468359
Atherosclerosis. 2008 Aug;199(2):445-50
pubmed: 18054939
Brain Res. 1993 Dec 17;631(1):27-38
pubmed: 8298993
Life Sci. 1986 Feb 3;38(5):389-401
pubmed: 3003479
J Biol Chem. 1996 Jul 12;271(28):16435-8
pubmed: 8663568
Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15862-15873
pubmed: 32561647
J Am Soc Nephrol. 2003 Oct;14(10):2611-7
pubmed: 14514739
J Neural Transm Suppl. 1990;30:57-67
pubmed: 1975266
Eur J Clin Nutr. 2009 Jan;63(1):150-2
pubmed: 18043699
Brain Res. 1987 Sep 22;421(1-2):280-90
pubmed: 3690274