Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation.
DNMT2
RNA cytosine methylation
epitranscriptomic
homeostasis
malaria
stress response
tRNA
tRNA cytosine methylation
tRNA modification
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
21 12 2021
21 12 2021
Historique:
pubmed:
3
11
2021
medline:
23
2
2022
entrez:
2
11
2021
Statut:
ppublish
Résumé
Malaria parasites need to cope with changing environmental conditions that require strong countermeasures to ensure pathogen survival in the human and mosquito hosts. The molecular mechanisms that protect Plasmodium falciparum homeostasis during the complex life cycle remain unknown. Here, we identify cytosine methylation of tRNA
Identifiants
pubmed: 34724812
doi: 10.1128/mBio.02558-21
pmc: PMC8561396
doi:
Substances chimiques
Protozoan Proteins
0
RNA, Protozoan
0
Cytosine
8J337D1HZY
RNA, Transfer
9014-25-9
Methyltransferases
EC 2.1.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0255821Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES002109
Pays : United States
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