A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol.
Animals
Avoidance Learning
/ physiology
Hippocampus
/ physiology
Hydroxycholesterols
/ metabolism
Lipopolysaccharides
/ immunology
Long-Term Potentiation
/ physiology
Mice
Mice, Inbred C57BL
Mice, Knockout
Microglia
/ metabolism
Neuroinflammatory Diseases
/ chemically induced
Rats
Rats, Sprague-Dawley
lipopolysaccharide
long-term potentiation
memory
metaplasticity
neurosteroids
oxysterols
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
08 12 2021
08 12 2021
Historique:
received:
22
07
2021
revised:
12
10
2021
accepted:
17
10
2021
pubmed:
3
11
2021
medline:
1
1
2022
entrez:
2
11
2021
Statut:
ppublish
Résumé
Inflammatory cells, including macrophages and microglia, synthesize and release the oxysterol 25-hydroxycholesterol (25HC), which has antiviral and immunomodulatory properties. Here, we examined the effects of lipopolysaccharide (LPS), an activator of innate immunity, on 25HC production in microglia, and the effects of LPS and 25HC on CA1 hippocampal synaptic plasticity and learning. In primary microglia, LPS markedly increases the expression of cholesterol 25-hydroxylase (Ch25h), the key enzyme involved in 25HC synthesis, and increases the levels of secreted 25HC. Wild-type microglia produced higher levels of 25HC than
Identifiants
pubmed: 34725187
pii: JNEUROSCI.1502-21.2021
doi: 10.1523/JNEUROSCI.1502-21.2021
pmc: PMC8660051
doi:
Substances chimiques
Hydroxycholesterols
0
Lipopolysaccharides
0
25-hydroxycholesterol
767JTD2N31
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10054-10064Subventions
Organisme : NIMH NIH HHS
ID : P50 MH122379
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH101874
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH123748
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH114866
Pays : United States
Informations de copyright
Copyright © 2021 the authors.
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