The Novel Dual Topoisomerase Inhibitor P8-D6 Shows Anti-myeloma Activity


Journal

Molecular cancer therapeutics
ISSN: 1538-8514
Titre abrégé: Mol Cancer Ther
Pays: United States
ID NLM: 101132535

Informations de publication

Date de publication:
01 2022
Historique:
received: 05 02 2021
revised: 04 10 2021
accepted: 28 10 2021
pubmed: 3 11 2021
medline: 31 3 2022
entrez: 2 11 2021
Statut: ppublish

Résumé

P8-D6 is a novel dual inhibitor of human topoisomerase I (TOP1) and II (TOP2) with broad pro-apoptotic antitumor activity. NCI-60 screening revealed markedly improved cytotoxicity of P8-D6 against solid and leukemia cell lines compared with other single and dual topoisomerase inhibitors, for example, irinotecan, doxorubicin, or pyrazoloacridine. In this study, we investigated the capacity of P8-D6 to inhibit myeloma cell growth

Identifiants

pubmed: 34725192
pii: 1535-7163.MCT-21-0119
doi: 10.1158/1535-7163.MCT-21-0119
doi:

Substances chimiques

1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl (E)-2-(4-(3-oxo-3-(3-(trifluoromethoxy)phenyl)prop-1-en-1-yl)phenoxy)acetate 0
Naphthalenes 0
Topoisomerase II Inhibitors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

70-78

Informations de copyright

©2021 American Association for Cancer Research.

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Auteurs

Katja Klausz (K)

Division of Stem Cell Transplantation and Immunotherapy, Department of Internal Medicine II, University Hospital Schleswig-Holstein, Campus Kiel, and Christian-Albrechts-University, Kiel, Germany. Katja.Klausz@uksh.de.

Christian Kellner (C)

Department of Transfusion Medicine, Cell Therapeutics and Hemostaseology, University Hospital, LMU Munich, Munich, Germany.

Carina Lynn Gehlert (CL)

Division of Stem Cell Transplantation and Immunotherapy, Department of Internal Medicine II, University Hospital Schleswig-Holstein, Campus Kiel, and Christian-Albrechts-University, Kiel, Germany.

Steffen Krohn (S)

Division of Stem Cell Transplantation and Immunotherapy, Department of Internal Medicine II, University Hospital Schleswig-Holstein, Campus Kiel, and Christian-Albrechts-University, Kiel, Germany.

Hauke Wilcken (H)

Division of Stem Cell Transplantation and Immunotherapy, Department of Internal Medicine II, University Hospital Schleswig-Holstein, Campus Kiel, and Christian-Albrechts-University, Kiel, Germany.

Inken Floerkemeier (I)

Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Kiel, Germany.

Andreas Günther (A)

Helios Clinics Schwerin, Hematology/Oncology/Stem Cell Transplantation, Schwerin, Germany.

Dirk O Bauerschlag (DO)

Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Kiel, Germany.

Bernd Clement (B)

Department of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Institute, Christian-Albrechts-University, Kiel, Germany.

Martin Gramatzki (M)

Division of Stem Cell Transplantation and Immunotherapy, Department of Internal Medicine II, University Hospital Schleswig-Holstein, Campus Kiel, and Christian-Albrechts-University, Kiel, Germany.

Matthias Peipp (M)

Division of Stem Cell Transplantation and Immunotherapy, Department of Internal Medicine II, University Hospital Schleswig-Holstein, Campus Kiel, and Christian-Albrechts-University, Kiel, Germany.

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