Toxicokinetic and bioavailability studies on retrorsine in mice, and ketoconazole-induced alteration in toxicokinetic properties.
LC-MS/MS
bioavailability
retrorsine
toxicokinetics
Journal
Biomedical chromatography : BMC
ISSN: 1099-0801
Titre abrégé: Biomed Chromatogr
Pays: England
ID NLM: 8610241
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
revised:
22
10
2021
received:
27
07
2021
accepted:
23
10
2021
pubmed:
3
11
2021
medline:
2
2
2022
entrez:
2
11
2021
Statut:
ppublish
Résumé
Retrorsine (RTS) is a toxic retronecine-type pyrrolizidine alkaloid, which is widely distributed. The purpose of this study was to develop a high-performance liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for serum RTS determination in mice. Serum samples were deproteinated by acetonitrile, separated on a C
Substances chimiques
Pyrrolizidine Alkaloids
0
Ketoconazole
R9400W927I
retrorsine
XJ86XWL8IY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e5270Subventions
Organisme : National Natural Science Foundation of China
ID : 81803623
Organisme : National Natural Science Foundation of China
ID : U1812403
Organisme : Natural Science Foundation of Guizhou Province
ID : [2019]1257
Informations de copyright
© 2021 John Wiley & Sons, Ltd.
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