DNA Methylation Abnormalities and Altered Whole Transcriptome Profiles after Switching from Combustible Tobacco Smoking to Heated Tobacco Products.
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
07
04
2021
revised:
29
08
2021
accepted:
18
10
2021
pubmed:
4
11
2021
medline:
12
3
2022
entrez:
3
11
2021
Statut:
ppublish
Résumé
The use of heated tobacco products (HTP) has increased exponentially in Japan since 2016; however, their effects on health remain a major concern. Tsuruoka Metabolome Cohort Study participants ( Ten of the 17 genes were significantly hypomethylated in CS and HTP users compared with NS, among which HTP users (switched from CS <2 years) display abnormal DNAm and transcriptome profiles, albeit to a lesser extent than the CS. However, because the molecular genetic effects of long-term HTP use are still unknown, long-term molecular epidemiologic studies are needed. This study provides new insights into the molecular genetic effects on DNAm and transcriptome profiles in HTP users who switched from CS.
Sections du résumé
BACKGROUND
The use of heated tobacco products (HTP) has increased exponentially in Japan since 2016; however, their effects on health remain a major concern.
METHODS
Tsuruoka Metabolome Cohort Study participants (
RESULTS
Ten of the 17 genes were significantly hypomethylated in CS and HTP users compared with NS, among which
CONCLUSIONS
HTP users (switched from CS <2 years) display abnormal DNAm and transcriptome profiles, albeit to a lesser extent than the CS. However, because the molecular genetic effects of long-term HTP use are still unknown, long-term molecular epidemiologic studies are needed.
IMPACT
This study provides new insights into the molecular genetic effects on DNAm and transcriptome profiles in HTP users who switched from CS.
Identifiants
pubmed: 34728466
pii: 1055-9965.EPI-21-0444
doi: 10.1158/1055-9965.EPI-21-0444
pmc: PMC9398167
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
269-279Informations de copyright
©2021 The Authors; Published by the American Association for Cancer Research.
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