Biomarkers of subclinical atherosclerosis in patients with psoriasis.

Atherosclerosis / diagnosis Biomarkers / analysis Cardiovascular Diseases / diagnosis Carotid Arteries / pathology Female Humans Lymphocytes / pathology Male Middle Aged Neutrophils / pathology Psoriasis / complications Risk Factors

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
02 11 2021
Historique:
received: 06 06 2021
accepted: 20 10 2021
entrez: 3 11 2021
pubmed: 4 11 2021
medline: 27 1 2022
Statut: epublish

Résumé

Psoriasis is linked with increased risk of cardiovascular disease (CVD) that is underestimated by traditional risk stratification. We conducted a large-scale plasma proteomic analysis by use of a proximity extension assay in 85 patients with a history of moderate-to-severe psoriasis with or without established atherosclerotic CVD. Differentially expressed proteins associated with CVD were correlated with subclinical atherosclerotic markers including vascular inflammation determined by

Identifiants

DOI: 10.1038/s41598-021-00999-9 PMID: 34728734 PMC: PMC8564536
pubmed: 34728734
doi: 10.1038/s41598-021-00999-9
pii: 10.1038/s41598-021-00999-9
pmc: PMC8564536
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

21438

Subventions

Organisme : LEO Fondet
ID : LF16115

Informations de copyright

© 2021. The Author(s).

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Auteurs

Hannah Kaiser (H)

Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark. lilian.hannah.kaiser@regionh.dk.
Department of Dermatology and Allergy, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark. lilian.hannah.kaiser@regionh.dk.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. lilian.hannah.kaiser@regionh.dk.

Xing Wang (X)

Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Amanda Kvist-Hansen (A)

Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.
Department of Dermatology and Allergy, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Martin Krakauer (M)

Department of Clinical Physiology and Nuclear Medicine, Herlev and Gentofte Hospital, Hellerup, Denmark.
Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, University Hospital, Copenhagen, Denmark.

Peter Michael Gørtz (PM)

Department of Clinical Physiology and Nuclear Medicine, Herlev and Gentofte Hospital, Hellerup, Denmark.

Benjamin D McCauley (BD)

Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Lone Skov (L)

Department of Dermatology and Allergy, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Christine Becker (C)

Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Peter Riis Hansen (PR)

Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › Biomarkers of subclinical atherosclerosis in...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Biomarkers of subclinical atherosclerosis in...
questionsmedicales.fr › Maladies cardiovasculaires › Biomarkers of subclinical atherosclerosis in...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Artères carotides › Biomarkers of subclinical atherosclerosis in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Biomarkers of subclinical atherosclerosis in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Biomarkers of subclinical atherosclerosis in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Biomarkers of subclinical atherosclerosis in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › Biomarkers of subclinical atherosclerosis in...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses papulosquameuses › Psoriasis › Biomarkers of subclinical atherosclerosis in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Biomarkers of subclinical atherosclerosis in...