Association of changes in lipid levels with changes in vitamin D levels in a real-world setting.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
02 11 2021
02 11 2021
Historique:
received:
25
05
2021
accepted:
13
09
2021
entrez:
3
11
2021
pubmed:
4
11
2021
medline:
22
1
2022
Statut:
epublish
Résumé
In clinical trials, vitamin D supplementation has been reported to reduce serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) but not high-density lipoprotein cholesterol (HDL-C). In this cohort study we evaluated the association between changes in vitamin D (25-hydroxyvitamin D) and changes in lipid levels in a real-world setting. Changes in lipid levels over a 1-year period were evaluated among individuals whose vitamin D levels increased (group 1) or decreased (group 2) by ≥ 10 ng/mL in year 2018 versus 2017 (cohort 1; n = 5580), in 2019 versus 2018 (cohort 2, n = 6057), or in 2020 versus 2019 (cohort 3, n = 7249). In each cohort, levels of TC, LDL-C, and TG decreased in group 1 and increased in group 2. Between-group differences in average changes in the 3 cohorts ranged from 10.71 to 12.02 mg/dL for TC, from 7.42 to 8.95 mg/dL for LDL-C, and from 21.59 to 28.09 mg/dL for TG. These differences were significant after adjusting for age, sex, race, education, body mass index, blood pressure, smoking status, geographical location, and baseline levels of vitamin D and lipids (P < 0.001). Changes in vitamin D levels were not significantly associated with changes in HDL-C levels.
Identifiants
pubmed: 34728785
doi: 10.1038/s41598-021-01064-1
pii: 10.1038/s41598-021-01064-1
pmc: PMC8563916
doi:
Substances chimiques
Biomarkers
0
Cholesterol, HDL
0
Cholesterol, LDL
0
Lipids
0
Triglycerides
0
Vitamins
0
Vitamin D
1406-16-2
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
21536Informations de copyright
© 2021. The Author(s).
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