Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 4:
amoxicillin
antimicrobial resistance
food‐producing animals
growth promotion
penicillin V
sub‐inhibitory concentration
yield increase
Journal
EFSA journal. European Food Safety Authority
ISSN: 1831-4732
Titre abrégé: EFSA J
Pays: United States
ID NLM: 101642076
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
entrez:
3
11
2021
pubmed:
4
11
2021
medline:
4
11
2021
Statut:
epublish
Résumé
The specific concentrations of amoxicillin and penicillin V in non-target feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC, it was not possible to conclude the assessment until further experimental data become available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/increased yield were reported for amoxicillin, whilst for penicillin V no suitable data for the assessment were available. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for these two antimicrobials.
Identifiants
pubmed: 34729084
doi: 10.2903/j.efsa.2021.6855
pii: EFS26855
pmc: PMC8547409
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e06855Informations de copyright
© 2021 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
Références
Br J Nutr. 2007 Jun;97(6):1128-37
pubmed: 17381960
J Antimicrob Chemother. 2000 Dec;46(6):909-15
pubmed: 11102409
Equine Vet J. 1990 Jul;22(4):290-1
pubmed: 2120035
J Anim Sci. 1996 Jul;74(7):1541-7
pubmed: 8818798
J Anim Sci. 2011 Dec;89(12):4043-53
pubmed: 21724943
Antimicrob Agents Chemother. 1994 Apr;38(4):842-7
pubmed: 8031056
Microb Drug Resist. 1995 Summer;1(2):103-9
pubmed: 9158741
J Aquat Anim Health. 2015 Mar;27(1):32-7
pubmed: 25581260
J Vet Pharmacol Ther. 1994 Apr;17(2):160-2
pubmed: 8040937
J Nutr Metab. 2012;2012:545341
pubmed: 22315674
Microbiology (Reading). 2018 Feb;164(2):142-153
pubmed: 29393019
BMC Genomics. 2017 Mar 20;18(1):241
pubmed: 28320307
Antimicrob Agents Chemother. 1998 Nov;42(11):2914-8
pubmed: 9797225
Poult Sci. 1990 Nov;69(11):1966-73
pubmed: 2128401
Can J Comp Med. 1976 Apr;40(2):175-83
pubmed: 63311
J Vet Pharmacol Ther. 1992 Sep;15(3):221-30
pubmed: 1433484
J Bacteriol. 2005 Feb;187(4):1515-8
pubmed: 15687217
Adv Appl Microbiol. 1973;16:1-54
pubmed: 4584679
Vet Res Commun. 2004 Oct;28(7):599-607
pubmed: 15563107
Antimicrob Agents Chemother. 2019 Sep 23;63(10):
pubmed: 31332059
J Anim Sci. 1999 Dec;77(12):3208-14
pubmed: 10641865
J Anim Sci. 1988 Oct;66(10):2598-605
pubmed: 3198539
Vet Rec. 1992 Feb 15;130(7):138-9
pubmed: 1557880
Foodborne Pathog Dis. 2013 Sep;10(9):805-12
pubmed: 23808851
PLoS One. 2013 Apr 23;8(4):e61083
pubmed: 23637786
Environ Int. 2016 Jan;86:140-9
pubmed: 26590482
mSphere. 2021 Apr 28;6(2):
pubmed: 33910990
J Vet Pharmacol Ther. 2009 Oct;32(5):506-9
pubmed: 19754920
Poult Sci. 1988 Mar;67(3):434-9
pubmed: 3405921
APMIS. 1999 Jun;107(6):585-92
pubmed: 10379686
Antimicrob Agents Chemother. 1999 May;43(5):1177-82
pubmed: 10223932
J Nutr. 1992 Dec;122(12):2383-90
pubmed: 1453223
Cold Spring Harb Perspect Med. 2016 May 02;6(5):
pubmed: 27091943
Zentralbl Veterinarmed B. 1999 May;46(4):261-9
pubmed: 10379236
J Dairy Sci. 2019 Mar;102(3):2298-2307
pubmed: 30692007
Antimicrob Agents Chemother. 1999 Jul;43(7):1669-73
pubmed: 10390220
J Anim Sci. 2003 Jun;81(6):1456-63
pubmed: 12817493
Poult Sci. 2019 Jun 1;98(6):2598-2607
pubmed: 30690607
J Vet Pharmacol Ther. 2007 Dec;30(6):550-5
pubmed: 17991223
Clin Microbiol Rev. 2020 Feb 26;33(2):
pubmed: 32102899
PLoS One. 2018 May 25;13(5):e0197353
pubmed: 29799833
Avian Pathol. 2006 Jun;35(3):230-7
pubmed: 16753615
Poult Sci. 1971 Jan;50(1):273-8
pubmed: 5550472
J Vet Pharmacol Ther. 1987 Mar;10(1):17-22
pubmed: 3108520
Vet Microbiol. 2007 Mar 31;121(1-2):94-104
pubmed: 17187945
Poult Sci. 2017 Sep 1;96(9):3068-3078
pubmed: 28595274
J Anim Sci. 1988 May;66(5):1100-8
pubmed: 3397336
Poult Sci. 1984 Oct;63(10):2036-42
pubmed: 6093090
Science. 1994 Apr 15;264(5157):388-93
pubmed: 8153626
J Vet Pharmacol Ther. 1998 Feb;21(1):41-6
pubmed: 9507456
Antimicrob Agents Chemother. 2014 Sep;58(9):5306-14
pubmed: 24957836
J Antimicrob Chemother. 2012 Dec;67(12):2854-9
pubmed: 22915457
Equine Vet J. 1988 Mar;20(2):125-7
pubmed: 3371314
Open Biol. 2015 Oct;5(10):
pubmed: 26468132
Am J Vet Res. 1988 Oct;49(10):1688-94
pubmed: 3189983
J Vet Pharmacol Ther. 2021 Jan;44(1):126-130
pubmed: 33063331
Antimicrob Agents Chemother. 2018 Sep 24;62(10):
pubmed: 30061284
Annu Rev Biochem. 2015;84:577-601
pubmed: 26034890
J Anim Sci. 1984 Apr;58(4):801-4
pubmed: 6725148
J Microbiol Biotechnol. 2015 Apr;25(4):431-8
pubmed: 25370726
Am J Vet Res. 1977 Jul;38(7):1007-13
pubmed: 883706
J Antimicrob Chemother. 2016 May;71(5):1188-98
pubmed: 26869688
J Bacteriol. 2006 Apr;188(7):2726-9
pubmed: 16547063
J Anim Sci. 1989 Sep;67(9):2341-6
pubmed: 2599977
Antimicrob Agents Chemother. 2010 Mar;54(3):969-76
pubmed: 19995920
J Antimicrob Chemother. 2011 Mar;66(3):531-8
pubmed: 21212055
Microb Drug Resist. 1995 Spring;1(1):85-94
pubmed: 9156388
J Anim Sci. 2012 Jan;90(1):252-60
pubmed: 21890507
Cold Spring Harb Perspect Med. 2016 Aug 01;6(8):
pubmed: 27329032
Br Vet J. 1966 Mar;122(3):112-6
pubmed: 5909024
Front Microbiol. 2016 Oct 06;7:1581
pubmed: 27766095
J Vet Pharmacol Ther. 2011 Apr;34(2):202-5
pubmed: 21395615
Future Microbiol. 2012 Mar;7(3):395-410
pubmed: 22393892
Avian Pathol. 1996 Sep;25(3):449-58
pubmed: 18645871