COVID-19 in patients with diabetes: factors associated with worse outcomes.
Antibiotics
Antiviral
COVID-19
Comorbidities
Diabetes
Journal
Journal of diabetes and metabolic disorders
ISSN: 2251-6581
Titre abrégé: J Diabetes Metab Disord
Pays: Switzerland
ID NLM: 101590741
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
07
06
2021
accepted:
24
09
2021
pubmed:
4
11
2021
medline:
4
11
2021
entrez:
3
11
2021
Statut:
epublish
Résumé
Diabetes is one of the major comorbidities associated with COVID-19. We aimed to determine the clinical and epidemiological factors associated with the mortality of COVID-19 in diabetic patients in Iran, and also the impact of prescribed antiviral and antibiotics on patients' status. In this study, we used the national registry of hospitalized patients with Severe Acute Respiratory Syndrome (SARS) Symptoms with diabetes from February 18, 2020, to December 22, 2020. Demographic, clinical features, treatments, concurrent comorbidities, and their associations with mortality and severity outcomes were assessed using logistic regression. 78,554 diabetic in-patients with SARS symptoms were included from 31 provinces of whom 37,338 were PCR positive for COVID-19. Older age and male gender are associated with COVID-19 mortality in diabetic patients. CVD is the most frequent comorbidity (42%). CVD, kidney disease, liver disease, and COPD are associated comorbidities which increased the risk of mortality. The mortality rate is higher in diabetic patients comparing to patients with no comorbidities, particularly in younger age groups. The frequency of antiviral, and antibiotics in COVID-19 positive patients was 34%, and 31%, respectively. Antibiotic treatment has no association with mortality in COVID-19 patients. Diabetic patients indicate higher mortality comparing to patients without any underlying comorbidities. Restrict strategies on increasing effective health care utilization must be considered in diabetic patients, especially in those with parallel underlying comorbidities. Regarding the antibiotic resistance issue and the noticeable use of antibiotics in diabetic patients, it is recommended to prioritize an antibiotic guideline prescription in COVID-19 patients for better stewardship by countries.
Identifiants
pubmed: 34729367
doi: 10.1007/s40200-021-00910-3
pii: 910
pmc: PMC8553287
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1605-1614Informations de copyright
© Springer Nature Switzerland AG 2021.
Déclaration de conflit d'intérêts
Conflict of interestOn behalf of all authors, the corresponding author states that there is no conflict of interest.
Références
Intensive Care Med. 2020 Apr;46(4):576-578
pubmed: 32077996
Nat Microbiol. 2020 Jun;5(6):779
pubmed: 32433531
JAMA. 2020 May 12;323(18):1839-1841
pubmed: 32215647
Int J Risk Saf Med. 2020;31(3):111-116
pubmed: 32474476
Nature. 2020 Aug;584(7821):430-436
pubmed: 32640463
J Clin Endocrinol Metab. 2020 Sep 1;105(9):
pubmed: 32498085
Lancet Diabetes Endocrinol. 2020 Sep;8(9):782-792
pubmed: 32687793
JAMA. 2020 May 12;323(18):1775-1776
pubmed: 32203977
Lancet Diabetes Endocrinol. 2020 Oct;8(10):813-822
pubmed: 32798472
Lancet. 2020 Aug 22;396(10250):532-533
pubmed: 32798449
J Diabetes Sci Technol. 2020 Jul;14(4):813-821
pubmed: 32389027
Emerg Microbes Infect. 2020 Dec;9(1):991-993
pubmed: 32342724
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Front Med (Lausanne). 2020 Jul 31;7:480
pubmed: 32850922
Diabetes Care. 2020 Jul;43(7):1382-1391
pubmed: 32409504
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Travel Med Infect Dis. 2020 Mar - Apr;34:101623
pubmed: 32179124
Lancet. 2020 Oct 3;396(10256):936-937
pubmed: 32896293
N Engl J Med. 2020 Jun 11;382(24):2372-2374
pubmed: 32302078
Diabetes Care. 2020 Jul;43(7):1399-1407
pubmed: 32409498
Chin Med J (Engl). 2020 May 5;133(9):1032-1038
pubmed: 32118640
Diabetes Care. 2003 Jan;26 Suppl 1:S33-50
pubmed: 12502618
JAMA Intern Med. 2020 Jul 1;180(7):934-943
pubmed: 32167524
J Diabetes. 2020 Sep;12(9):659-667
pubmed: 32401405
Lancet Respir Med. 2020 Apr;8(4):e21
pubmed: 32171062
Lancet Rheumatol. 2021 Jan;3(1):e2-e3
pubmed: 33521667
Cell Death Dis. 2020 Jul 8;11(7):512
pubmed: 32641681
N Engl J Med. 1999 Dec 16;341(25):1906-12
pubmed: 10601511
Front Med (Lausanne). 2020 May 06;7:199
pubmed: 32435649
Nat Rev Cardiol. 2020 Sep;17(9):543-558
pubmed: 32690910
Crit Care. 2020 Jul 9;24(1):410
pubmed: 32646494
Lancet Diabetes Endocrinol. 2020 Oct;8(10):823-833
pubmed: 32798471